JohnCCha wrote:With this, I would like to address some key points that were not understood/misunderstood.
Thank you Mr. Cha for coming here to address these points. I'm pleased that the first author on the study under discussion would take the time to do so. I personally found your research very interesting and important, and your comment that "Maeda
DID NOT find atherosclerosis in the Gulo-/- mouse with total vitamin C deprivation..." points to the important difference that in your study, you demonstrated the actual vascular deposition of lipoprotein(a) under hypoascorbemic conditions.
JohnCCha wrote:The transgenic knockout mouse is a system to study human atherogenesis in a mouse. Some things are the same, other things are different such as size and dimension.
It occurs to me that your particular mouse model might be appropriate to assess the question of whether the inclusion in the diet of large amounts of proline/lysine actually can help prevent the deposition of lipoprotein(a).
All the best to you also, and Happy New Year!
Douglas Q. Kitt, founder of ReCverin LLC, sellers of stabilized dehydroascorbic acid solutions.