Advanced glycation end products (AGEs)

The discussion of the Linus Pauling vitamin C/lysine invention for chronic scurvy

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gmdodaro
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Advanced glycation end products (AGEs)

Post Number:#1  Post by gmdodaro » Sat Nov 14, 2015 4:46 pm

Here's link to an article I recently found that includes useful information against heart disease.
http://www.lifeextension.com/magazine/2 ... ar/page-01

Block The Aging Effects Of High Blood Sugar
Glycation—the deadly binding of sugars to proteins—produces deadly byproducts called advanced glycation end products (AGEs).
AGEs damage cells, tissues, and organs, and cause premature aging.
Thiamine is the body’s natural defense against AGEs, but since it is water soluble, the body doesn’t absorb it well.
Benfotiamine, a fat-soluble derivative of thiamine (vitamin B1), substantially boosts intracellular thiamine levels, inhibiting the AGEs that cause sugar-related damage to tissue.
Numerous studies demonstrate that benfotiamine blocks the pathways of Alzheimer’s disease, vision loss, cardiovascular disease, and kidney damage.
Benfotiamine is extremely safe and appears to slow the chronic disease and aging effects of glycation in nondiabetic as well as diabetic individuals.

gmdodaro
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Re: Advanced glycation end products (AGEs)

Post Number:#2  Post by gmdodaro » Sat Nov 14, 2015 4:49 pm

Benfotiamine Protects Against Cardiovascular Damage
The thin layer of endothelial cells that lines blood vessels constantly regulates blood pressure and flow. Advanced glycation end products damage these cells, which can lead to heart attacks, heart failure, and stroke.54,55

Advanced glycation end products damage blood vessels in three ways:

They reduce endothelial cell replication, a vital process to keep arteries healthy.56
They trigger an increased level of death among endothelial cells.57
They produce toxic polyol compounds, which disrupt the functioning of vascular and endothelial cells.58

Remarkably, studies indicate that benfotiamine protects endothelial cells from all three of these damaging effects of AGEs.56-58 This protection ultimately improves the functioning of blood vessels and heart muscle.59,60

An interesting study on humans revealed just what a dramatic impact these effects would have on heart health. In the study, subjects took 1,050 mg of benfotiamine per day for three days. The scientists wanted to determine the effect benfotiamine would have on the changes in endothelial function and blood flow that occur as a result of consuming a meal rich in advanced glycation end products.59 The striking outcome of supplementation revealed that benfotiamine completely prevented endothelial and blood flow impairment!26,61

Benfotiamine also counters the negative effects of oxidative stress on blood vessels. In a study in which rodents were experimentally induced with vascular endothelial dysfunction, supplemental benfotiamine resulted in improved endothelial integrity and function by enhancement of production of nitric oxide, a compound that helps blood vessels to relax.53,73

Blood sugar and advanced glycation end products greatly contribute to the diminished heart-muscle function known as heart failure, which can be caused by a heart attack or untreated high blood pressure. Scientists have demonstrated that benfotiamine helps normalize the heart muscle’s ability to contract, salvaging damaged heart muscle and improving its capacity to effectively pump blood.60

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Re: Advanced glycation end products (AGEs)

Post Number:#3  Post by gmdodaro » Sat Nov 14, 2015 4:59 pm

Here is another paragraph that got my attention:
Blood sugar and advanced glycation end products greatly contribute to the diminished heart-muscle function known as heart failure, which can be caused by a heart attack or untreated high blood pressure. Scientists have demonstrated that benfotiamine helps normalize the heart muscle’s ability to contract, salvaging damaged heart muscle and improving its capacity to effectively pump blood.60

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Re: Advanced glycation end products (AGEs)

Post Number:#4  Post by Johnwen » Sat Nov 14, 2015 10:31 pm

L-Carnosine does a excellent job at reversing AGE. It takes a while to reach max. effectiveness, however there is good reduction within 24 hours of dosing.
As far as price it's a little on the higher side. 100 pills 500mg. is @ $40.00

I take 500mg 2x a day been doing it for about 3 years. Guess it's doing me good??? Haven't stopped them to see if I feel any difference.

Here's a link to a study on them! PDF File

http://www.pdiconnect.com/content/27/1/86.full.pdf
To steal ideas from one person is plagiarism. To steal from many is
research!

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Re: Advanced glycation end products (AGEs)

Post Number:#5  Post by gmdodaro » Sun Nov 15, 2015 11:23 pm

Thanks, Johnwen!
This looks like a pretty good price for 60 500 mg caps: http://www.swansonvitamins.com/q?kw=carnosine

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Re: Advanced glycation end products (AGEs)

Post Number:#6  Post by Herrybraun » Wed Aug 01, 2018 11:21 am

I really admire your information about AGEs. Thankful to you.


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