So does serrapeptase dissolve plaque?
What about other proteolytic enzymes?
Bumping thread for any answers ...
Some anwers here:
Evidence suggests that trypsin, papain, and other proteolytic enzymes can break up existing pathogenic immune complexes and even prevent their formation in the first place, enhancing lymphatic drainage.
https://nutritionreview.org/2013/04/controlling-inflammation-proteolytic-enzymes/ the lipases along with nattokinase and/or other proteases help maintain a good blood flow rheology, ensuring delivery of nutrients
https://enzyscience.com/blogs/news/32969731-proteolytic-enzymes-a-novel-approach-in-cardiovascular-dietary-supplementationSerrapeptase
.... Clinical trials support Serrapeptase ability to benefit chronic sinusitis, fibrocystic breast disease, edema, and plaque accumulations in arteries.
Proteinase
... removes toxic waste and excess free radials that inhibit recovery and cancer. Coupled with Serrapeptase, creates even more fibrinolytic benefits
Nattokinase
Nattokinase is a potent fibrinolytic enzyme .. . could successfully dissolve thrombus
https://michelle-honda-blog.renewyou.ca/proteolytic-enzymes-cancer-and-more/Bromelain
[Animal trials] Results suggested that bromelain could be used for treating acute thrombophlebitis, as it decreases aggregation of blood platelets, has a cardio-protective effect, ameliorates rejection-induced arterial wall remodelling, prevents thrombin-induced human platelet aggregation as well as reduces thrombus formation.
https://www.researchgate.net/publication/51486315_A_review_of_the_use_of_bromelain_in_cardiovascular_diseases/link/00b7d51dbbc25e5ac6000000/downloadhttps://www.drweil.com/health-wellness/body-mind-spirit/heart/serratiopeptidase-enzyme-to-fight-heart-threat/ suggests serrapeptase is an anti-inflammatory but does not have the power to remove plaque.
HOWEVER:
dangerous plaques in blood vessels can rupture by overproducing protein-digesting enzymes.
Some scientists have suspected that an excessive production of protein-digesting enzymes might be linked to ‘vulnerable plaque’ — blood vessel lesions prone to rupture. The findings of our study offer the best cause and effect evidence to date that this is likely the case.
....
The researchers also observed that the increase in urokinase upped the activity of other protein-digesting enzymes that can eat away at the structural proteins that hold a plaque together. These other enzymes can weaken the framework of the plaque and also promote the self-destruction of nearby smooth muscle cells in the artery.
These enzymes belong to a large family of remodeling enzymes called matrix metalloproteinases, or MMPs. The exact form of MMP implicated in this study hasn’t been determined. Like urokinase, MMPs have helpful roles, depending on the location and circumstances in the body.
Urokinase also activates a substance in blood vessels called plasminogen and turns it into plasmin, another protein-destroying enzyme. In several studies, patients whose blood tests showed a high level of plasminogen activation had an elevated risk of future heart attacks and strokes.
https://www.washington.edu/news/2010/03/29/dangerous-plaques-in-blood-vessels-rupture-by-overproducing-protein-busting-enzymes/So taking proteolytic enzymes while one has blocked arteries may not be such a good idea. Anyone agree?And just to complicate the issue :
...reversal of atherosclerosis was accomplished with NK [Nattokinase]. In 26 weeks plaque volume fell by 37%.
... Dr. Wong HATES nattokinase. Of all the proteolyticenzymes it is the only one that does not have a feedback mechanism to let it know when to stop lysing, (i.e. eating) blood proteins.
In nature nattokinase is always found with Vitamin K1 and that prevents the blood from becoming overly thin when eating the natto curd and taking in the nattokinase enzyme. When the nattokinase is extracted from that curd, the Vitamin K is left extracted from that curd, the Vitamin K is left behind. So, of all the proteolytic enzymes it is the one most likely to create the danger of overly thin blood and cause hemorrhagic bleeding issues.
Though nattokinase is highly touted by health food industry hype, the Handbook of Proteolytic Enzymes tells us that nattokinase does not do anything that the serrapeptidase, trypsin, chymotrypsin or papain does not do, including clearing the excess fibrin and adhesion molecules as well as lysing away arterial plaque. In terms of fibrinolysis, nattokinase and In terms of fibrinolysis, nattokinase and serrapeptidase are nearly equal with the serrapeptidase having a slight advantage. Another advantage of using serrapeptidase and the other enzymes is they are considerably safer at doing that job than the nattokinase.
https://www.lifetraininginstitute.org/uploads/1/5/4/9/15495748/3_cleaning_out_arteries.pdf