THANK YOU for your response. I am currently taking 6 grams Lysine 6 grams Vitamin C, just upped it to 9 Grams, and 1.5 grams of Proline. I'm also taking a myriad of other supplements, K2, carnitine, Red Yeast Rice, High Absorbtion coQ10,Omega 3, Berberine, just to name a few. I'm 56, weigh 116, eat plant-based, exercise (hiking). I just got my bloodwork back a few days ago, and lo and behold, save for the off the charts Lp(a) numbers and beta-sitosterol, all values have *vastly* improved (results provided below). This youtube video states that is your Lp-PLA2 is good then high lipoprotein's risk is substantially diminished: https://youtu.be/f-LH8n9Olas
The main Lp(a) SNPS rs3798220 and rs10455872 both homozygous in my case = good. Apparently the heterozygous versions can contribute to aortic stenosis.
Ezetimibe blocks the cholesterol from being absorbed therefore has been recommended in my case as I am a cholesterol absorber rather than a cholesterol producer, as per the exceedingly high beta sitosterol number. I read that it blocks NPC1L1, which is the same pathway Vitamin K uses to get absorbed. I take K2 to hopefully remove calcified plaque. Also have wondered if a Bile supplement would help with sterol absorption, but read it possibly can cause cancer(!?) I have those dreaded earlobe creases, and when I had my first mammogram, there were micro-calcifications at age 40 which happens they say every 1 in 10 cases at that age, so who knows how long they were there. Will get Calcium scan to see how much damage has been done over the many years without even knowing about these markers. Thankfully my ultrasound of carotid/aorta was super clear. Owen, have you heard of Lp(a) being tied in with Hyperabsorption of cholesterol? I have been dealt, I believe a double whammy with high Lp(a) and high Beta Sitosterol absorption. However, if it is valid that low inflammation via LpPLA2 negates the damage of Lp(a), that is rather comforting.
I will resend the email to you regarding activating my membership to the Vitamin C Forum, as I would very much like to join in on the conversation.
July, 2018 Boston Heart Diagnostics : May 2016 True Health Diagnostics: Labcorp June 2016:
Total Cholesterol: 171 mg/dL Total Cholesterol: 229 Lp(a) ***Measured in nmol/L** 178 but a HUGE fluctuation from previous test
Direct LDL c 97 mg/dL LDL 161
HDL-C 77 mg/dL HDL 69
Triglycerides: 41 mg/dL Triglycerides 79
Lp(a) 131 mg/dL should be >50 Lp(a) **Measured here in nmol/L** 567 Should be >75
Fibrinogen 395 mg/dL Should be >370 Fibrinogen 530
Apo B 88 mg/dL should be >80 Apo B 118
CRP 0.6 mg/L CRP 1.8
LpPLA2 125 nmol/min/mL LpPLA2 209
MPO 324 pmol/L
Beta-Sitosterol 234 Super High( don’t know the reference range)
other sterols are in OK zone