A. Hoffer wrote:...I was very surprised by the argument that there is only a vitamin C complex and no such substance as vitamin C. In my opinion this is not a scientific matter but an important advertising problem...Synthetic vitamin C is bio-identical...
Steve Lawson wrote:...I was unaware that any such controversy about vitamin C exists. Actually, among scientists, there is no controversy about “natural” and “synthetic” vitamin C: it is exactly the same molecule, regardless of source. As far as vitamin C activity is concerned, the only substance in the so-called “vitamin C complex” that provides this is ascorbic acid. This has been well established for many decades and is not in question among professional scientists.
ToMyFriendsHealth wrote:From Albert Svent-Gyorgyi's presentation to the Nobel Committee in 1937 before his award for the Nobel Prize. Notice the comments on the vitamin P component. C, I'm sorry, is not ascorbic acid.
...At the time that I had just detected the rich vitamin content of the paprika, I was asked by a colleague of mine for pure vitamin C. This colleague him- self suffered from a serious haemorrhagic diathesis. Since I still did not have enough of this crystalline substance at my disposal then, I sent him paprikas. My colleague was cured. But later we tried in vain to obtain the same thera- peutic effect with pure vitamin C. Guided by my earlier studies into the peroxidase system, I investigated with my friend St. Rusznyák and his collaborators Armentano and Bentsáth the effect of the other link in the chain, the flavones. Certain members of this group of substances, the flava- none hesperidin (Fig. 5) and the formerly unknown eriodictyolglycoside, a mixture of which we had isolated from lemons and named citrin, now had the same therapeutic effect as paprika itself. It is still too early on in our experience for us to make any definitive statements. But it does seem that these substances possess great biological activity. They influence most ob-
OXIDATION, ENERGY TRANSFER, VITAMINS
viously the capillary blood vessels, whose permeability and resistance suffer gravely in many disease states. These dyes are able to restore the state of affairs to normal, and to judge by the first experiences, it seems that these substances will enrich the doctor’s inventory with a really useful new weapon for him to fight illnesses with. Our experiments made it probable that cer- tain members of this group possess vitamin-like properties. For this reason I called the substance vitamin P. Unfortunately these vitamin-like properties have not yet been successfully demonstrated in a completely irreproachable and reproducible fashion....
Notice the comment on the Vitamin P component.
It's a complex and not an isolate.
http://www.nobelprize.org/nobel_prizes/ ... ecture.pdf
And from the presentation speech by Professor E. Hammarsten, member of the Staff of Professors of the Royal Caroline Institute, on December 10, 1937
http://www.nobelprize.org/nobel_prizes/ ... press.html
Vitamin C, ascorbic acid - The name gives it away, there is no chemical difference between "natural" and "synthetic" vitamin C; it's both plain ascorbic acid. What is missing if you get your vitamin C in pill instead of apple, citrus-fruit and other food-born forms are yet the active form of vitamin C, dehydroascorbic acid (DHAA), and its natural synergists which are required for vitamin C to work optimally...
Studies have shown that the "bioavailability of vitamin C in food and 'natural form' supplements is not significantly different from that of pure synthetic AA" which is true, when we look at ascorbic acid in isolation like Mangels et al. (Mangels. 1993) did... Mangels et al. did yet ignore the individual and synergistic effects of DHAA or other food constituents associated with natural vitamin C which may have positive effects other than raising serum ascorbate levels. Preliminary data from Vinson et al. (1988) however suggests that vitamin C complexed in food is absorbed 1.74 times more into red blood cells than isolated USP ascorbic acid...
A result that leaves no doubt that simple serum vitamin C measurements as they are done in most studies may be insufficient to identify the subtle advantages of natural vitamin C which does not come in pill form...
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