1937 report: Some people need flavonoids to utilize vit C

What is vitamin C? Is there such a thing as a vitamin C complex? Why do so many people now believe in the complex?

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1937 report: Some people need flavonoids to utilize vit C

Post Number:#1  Post by VanCanada » Tue Mar 12, 2013 5:28 pm

Page 105 of the Stephen Sheffrey, D.D.S. book:

Steven Sheffrey wrote:......As mentioned, bioflavonoids aid in the absorption and utilization of C. [More is also absorbed from a C solution that is sipped slowly but the acid form will etch tooth enamel. Long-term use of the method is not advised.] Bioflavonoids are flavonoids the body can use. The trend is toward omitting "bio" and just calling them flavonoids. Some are powerful antioxidants. Some help prevent heart disease (Note 31). Some were once called vitamin P but the term was considered inappropriate by 1950.

......Plants differ in the type of flavonoid produced. Vitamin C extracted from plants in the 1930s contained about 2.5% impurities, probably including flavonoids. The impure C was more than twice as effective as synthetic C in preventing paralysis and death of monkeys infected with poliomyelitis (Note 32). The early belief that natural C is better than the synthetic product probably stemmed from that report. We can return our C to the "impure" state by taking it with added flavonoids or with fruits and vegetables. Citrus flavonoids appear to work well with C.

......Consider this 1937 report by two physicians, one a professor, at a university clinic in Copenhagen: Before synthetic C was available they cured scurvy with the juice of 5 to 10 lemons a day for a week or more. They switched to synthetic C after it became plentiful, giving 300 mg a day, the amount in the juice of 10 lemons. The synthetic C readily cured 26 of 29 patients---but had no effect on the other 3, not even when given intravenously! The 300 mg of injected C, equal to 600 mg of oral C, was in the bloodstream, available to the body but of no value because it could not be utilized. It even failed to raise the plasma C to normal. To achieve a cure it was necessary to give the patients lemon juice (Note 33). A look at the case histories of the 3 patients is of interest:

Quoted from:
Vitamin C: how best to use it: how improper clinical trials have misled us!: separating fact from fiction to ensure proper use / Stephen Sheffrey, D.D.S. -- 2nd ed. (2002)

ISBN: 0-9629372-3-1
Published by Service Press, Box 130104, Ann Arbor, MI 48113


Page 106 of Vitamin C: How Best to Use It

Post Number:#2  Post by VanCanada » Tue Mar 12, 2013 5:31 pm

Stephen Sheffrey wrote:Page 106:

......Case 1: A man, 24, had a history of diarrhea since age 7 and periods of ulcerative colitis since age 11 which improved in summer and fall when he ate fresh fruit and vegetables. All his teeth had been extracted. He bruised easily. At the start of treatment for scurvy his serum C was 0.02 to 0.03 mg per 100 ml. You'll recall that low normal is 0.4, more than 10 times the level found in this patient.

......Oral doses of synthetic C, 300 mg a day for 10 days, failed to raise the level; nor did the same dose given intravenously for a few days. The juice of 5 lemons a day for 3 days raised it to 0.04. Doubling the lemon juice boosted the level to 0.2 on the first day, still below normal but out of the severe scurvy range. After 3 more days on the juice of 10 lemons a day, C began to appear in the urine. At day 7 serum C level was 0.26 but rising so that 5 lemons a day supplied C for the next 16 days, during which time serum C level reached a peak of 0.84 mg/dl and the scurvy vanished.

......Case 2: For 15 years a man, 55, had experienced "hunger pain" and periods of gum disease. When seen in the clinic his stools were black due to bleeding in the gut. His serum C of 0.02 to 0.03 remained steady during his 5 days of observation. 300 mg of synthetic C raised the level to 0.04. No C appeared in the urine. The same dose given intravenously raised the serum C level to 0.08 while 40 to 180 mg of C per day passed in the urine.

......A switch to the juice of 10 lemons a day raised the C level to 0.69. Urinary C, which had not risen above 40 mg a day during the first 10 days jumped to 96 mg on day 11, indicating thta the body could spare more. Notice that urinary C from injection of the synthetic product was much greater, probably because the body couldn't use it, therefore dumped it.


Page 107 of Vitamin C: How Best to Use It

Post Number:#3  Post by VanCanada » Tue Mar 12, 2013 5:35 pm

Stephen Sheffrey wrote:......Case 3: A woman, 44, had experienced stomach and intestinal trouble for 12 years---dyspepsia, diarrhea, colitis and bloody stools. During a 5-day observation period her serum C varied from 0.02 to 0.025 mg/dl. Ten days of intravenous synthetic C raised serum C to 0.08, the same amount seen in case 2. The urinary output was identical also---40 to 180 mg a day. During the next 6 days she drank the juice of 52 lemons, about 9 a day, which raised serum C to 66 mg/dl. Its urinary output rose from zero at start to 36 mg on day 5; and 82 on day 6, a signal that the dose was adequate.

......The physicians noted the features these 3 patients had in common: an inability to absorb synthetic C or to utilize it when given intravenously; a response to lemon juice; and intestinal trouble of long duration. The lemon juice cured "both humoral and clinical abnormalities," which is to say that it restored serum C to normal and the diseased intestines to health. It appears that subclinical scurvy had targeted the intestines to cause discomfort for years before recognizable scurvy appeared. The most unusual feature is of course the inability to utilize C.

......If people having this rare condition existed in 1937, then wouldn't similar individuals exist today? Who are they? People who have tried all sorts of treatment without success? They may or may not be those with irritable-bowel syndrome, which sometimes responds to antibiotic therapy. But it would be interesting to know the plasma C level in the stubborn cases.


1937 report: Some people need flavonoids to utilize vit C

Post Number:#4  Post by VanCanada » Tue Mar 12, 2013 5:38 pm

I posted more quotes from this Sheffrey book at this thread:


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