Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

A discussion of Paul Marik's remarkable new therapy that cures a major killer in hospitals: Sepsis

Moderators: ofonorow, popnowlin

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 13372
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#1  Post by ofonorow » Sun May 13, 2018 6:21 am


youtube direct link


Early article

https://www.npr.org/sections/health-shots/2018/05/11/609149556/can-a-cocktail-of-vitamins-and-steroids-cure-a-major-killer-in-hospitals

Note: Vitamin D is a "steroid," Cholesterol is a "steriod," etc. The treatment is with hydrocortisone, which is bioidentical to our natural hormone cortisol. The other "steroids" of which they speak are much more familiar to medical doctors, e.g. prednisone. However, Dr. Marik's treatment is with hydrocortisone which (t least emergency room) doctors will have to become familiar with.
Owen R. Fonorow, Orthomolecular Naturopath

Johnwen
Ascorbate Wizard
Ascorbate Wizard
Posts: 2152
Joined: Sun Sep 20, 2009 5:27 pm
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#2  Post by Johnwen » Tue Oct 23, 2018 11:09 am

I just got around to reading this article and figured I could shed some light on it! :wink:

This cocktail entails Hydrocortisone, B1 (Thiamine) and V-C which is fine to a point where the rise in cortisol is going to suppress and lessen the bioavailability of V-D. This in turn opens the door to other problems associated with V-D deficiency.
In a patient with a critical condition this drop in V-D could and will have some bad effects on the patient.
So the old analogy of “What’s good for the Goose might not be good for the Gander !”

Here’s some links;
This one shows the balance scale effect of cortisol and V-D!

https://www.sciencedaily.com/releases/2 ... 144639.htm

This one talks about the different forms of V-D and which form is affected by cortisol! It’s a PDF File form AHA journal!

https://www.ahajournals.org/doi/pdf/10. ... 118.311585
To steal ideas from one person is plagiarism. To steal from many is
research!

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 13372
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#3  Post by ofonorow » Thu Oct 25, 2018 3:18 pm

Using steroids as a measure of vitamin D deficiency is entirely bogus. The first link doesn't specify which "steroids" are possibly linked to the deficiency... If any! And, since most doctors look at me sideways when I mentioned hydrocortisone, I am willing to wager a tidy sum that the "steroids" in this study were mostly the prednisones and other 'concentrated' forms of cortisol misprescribed by most docs - i.e.,in way to high a dosages.. (and not bio-identical cortisol.) Couldn't read more than the abstract in the second link.

So lets assume this isn't another targeted "hit pieces" designed to scare doctors away from "evil" steroids. And that for some reason, cortisol is antagonistic to vitamin D. Then ordinary, endogenous cortisol, i.e. STRESS should lower vitamin D levels. There should be studies of low vitamin D levels in people under chronic stress, for example.

I for one have no fear that the hydrocortisone used in Marik's sepsis protocol would have no, zero effect on Vitamin D levels, but if it did - the people should sit out in the sun for 20 minutes :D

And that brings to mind a more likely reason for the cause of the "severe" vitamin D deficiency: People on steroids are, almost by definition, in seriously bad shape. They majority are probably in hospitals or bed ridden, so they are not getting sunshine.
Owen R. Fonorow, Orthomolecular Naturopath

Johnwen
Ascorbate Wizard
Ascorbate Wizard
Posts: 2152
Joined: Sun Sep 20, 2009 5:27 pm
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#4  Post by Johnwen » Thu Oct 25, 2018 5:13 pm

There should be studies of low vitamin D levels in people under chronic stress, for example.


First lets interrupt what this means;
Chronic Stress effect is known as, “Allostatic Load!” which the condition it causes is called, “Allostasis!”

Here’s the Wiki’s on these two;

https://en.wikipedia.org/wiki/Allostasis

As you can see there’s two types;

Where as both types of allostasis are associated with increased release of cortisol and , catecholamine’s, they differentially affect thyroid homeostasis: Concentrations of the thyroid hormone triiodothyromine are decreased in type 1 allostasis, but elevated in type 2 allostasis.


Now let’s see what causes this;

https://en.wikipedia.org/wiki/Allostatic_load

Now we know what were talking about here and the BIG words used to describe it!
So lets see the study on this effect that Owen requested! There’s more but this long enough for now! 8)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599851/
To steal ideas from one person is plagiarism. To steal from many is
research!

confused1
Vitamin C Master
Vitamin C Master
Posts: 328
Joined: Wed Feb 15, 2017 2:41 pm
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#5  Post by confused1 » Sat Oct 27, 2018 3:35 pm

I guess the news still isn't out about curing septic shock. Paul Allen, the co-founder of Microsoft and a multi-billionaire, recently died of it.

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 13372
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#6  Post by ofonorow » Mon Oct 29, 2018 7:26 am

Agreed confused1.

johnwen, I love that "study" you referenced. Again, "linking" low vitamin D with poor health is easy, because people in poor health generally stay indoors or in bed! And no sunshine certainly contributes to their health!

First, separate "steroids" (e.g. prednisone or prednisilone) from cortisol/hydrocortisone (or vitamin D/cholesterol for that matter - both of which are steroids.) Most doctors prescribe the prednisones (and usually for serious conditions). These drugs are not bioidentical and something like 4-5 times more concentrated than hydrocortisone/cortisol. It really doesn't matter much what adverse affects these drugs create.

The argument is whether our own natural hormone (and its bioidentical cousin hydrocortisone) causes any problem in the dosages that Dr. Marik recommends for sepsis. I think the idea it may cause a vitamin D deficiency is a STRETCH, to say the least, since most people who are in septic shock or very ill would no doubt have a vitamin D deficiency, and the deficiency is more than likely playing a role in the infection!
Owen R. Fonorow, Orthomolecular Naturopath

OxC
Vitamin C Master
Vitamin C Master
Posts: 351
Joined: Tue Sep 17, 2013 1:25 pm
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#7  Post by OxC » Sun Nov 11, 2018 3:17 pm

Dr. Marik has published a new paper about his Hydrocortisone/Ascorbic acid/Thiamine (HAT) therapy for sepsis. https://www.preprints.org/manuscript/201810.0285/v1

This paper reviews the rationale for HAT therapy with a focus on vitamin C. Of particular interest to me, because of my special interest in the oxidized form of vitamin C (DHAA), are the following excerpts:
Dehydroascorbic acid is transported via the GLUT1 transporter into mitochondria, where it converted to ascorbic acid and acts as a potent antioxidant limiting mitochondrial oxidant injury. Considering that the mitochondrial respiratory chain is a main source of ROS in live cells and mitochondrial dysfunction plays a prominent role in sepsis pathogenesis, antioxidants targeting the intra-mitochondrial environment could be pivotal role in the treatment of sepsis.
Vitamin C suppresses activation of NF-κB by inhibiting tumor necrosis factor-α (TNFα) induced phosphorylation of inhibitory kappa-B kinase (IκB kinase)

The TNFα inhibition mechanism described above is a property of DHAA, not AA. AA has been reported to inhibit TNFα by a different mechanism, thus their combined effects may be synergistic and provide a powerful anti-inflammatory effect in sepsis.
Douglas Q. Kitt, founder of ReCverin LLC, sellers of stabilized dehydroascorbic acid solutions.

OxC
Vitamin C Master
Vitamin C Master
Posts: 351
Joined: Tue Sep 17, 2013 1:25 pm
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#8  Post by OxC » Mon Dec 03, 2018 9:33 pm

In this recent video of a lecture at Virginia Tech Carilion Research Institute, Dr. Alpha Fowler discusses the results of his Phase II trial of IVC in patients with Acute Respiratory Distress Syndrome caused by sepsis: Intravenous Vitamin C: Pathway to a New Therapy to Save Lives
Douglas Q. Kitt, founder of ReCverin LLC, sellers of stabilized dehydroascorbic acid solutions.

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 13372
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Re: Can A Cocktail Of Vitamins And Cortisol Cure A Major Killer In Hospitals?

Post Number:#9  Post by ofonorow » Fri Dec 21, 2018 7:29 am

Report of another trial starting and recruiting. Hard to believe they would subject half the patients to a "placebo" .

https://www.contagionlive.com/news/sepsis-treatment-trial-evaluates-vitamin-c-thiamine-and-steroid-combination
“If this study shows promising results for the combination therapy of vitamin C, thiamine, and corticosteroids in sepsis, it has the potential to impact millions of lives both in the United States and worldwide,” Dr. Nugent said. “Such a combination carries fewer risks and is more widely available than previously studied ancillary therapies, increasing its possible influence over this widespread, deadly, and costly public health crisis.”

The double-blind, placebo-controlled, adaptive randomized clinical trial will enroll as many as 2000 patients with sepsis to receive either the combination therapy or a placebo along with standard intensive medical treatment for sepsis, which includes high doses of antibiotics. The primary outcome for the study is vasopressor and ventilator-free days at 30 days (+/-3 days) after randomization, which will be determined by recording all start and stop days of these measures, according to the trial description.
Owen R. Fonorow, Orthomolecular Naturopath


Return to “Sepsis Cure: IV/C, Hydrocortisone and Vit B1 Protocol”

Who is online

Users browsing this forum: No registered users and 0 guests