Vitamin C Forum

Posted: **Wed Jun 08, 2022 11:03 am**

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

https://aacrjournals.org/cancerres/article-abstract/82/11/2097/699111/TET2-Suppresses-VHL-Deficiency-Driven-Clear-Cell?redirectedFrom=fulltext

Stimulating the TET2-FBP1 axis with vitamin C repressed the growth of VHL-deficient ccRCC with wild-type TET2 and increased the sensitivity to glycolysis inhibitors

This study reveals a unique function of TET2 in the suppression of tumor metabolism and HIF signaling, and it also provides therapeutic targets, potential drugs, and prognostic markers for the management of ccRCC.

Posted: **Wed Jun 08, 2022 9:45 pm**

I have had success in the past treating 2 cases of VHL, without genetic manipulation.
Was able to reverse the genetic defect, and they started producing the tumor suppressor protein, which wasn't being produced earlier leading to multiple tumors.

eDOC!!

Vitamin C Forum

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma (More with Vitamin C)

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma (More with Vitamin C)

Re: TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma (More with Vitamin C)