Investigating the individual and combined effects of coenzyme Q10 and vitamin C on CLP-induced cardiac injury in rats

[ofonorow]

https://www.nature.com/articles/s41598-024-52932-5

Sepsis-induced cardiac injury represents a major clinical challenge, amplifying the urgency for effective therapeutic interventions. This study aimed to delve into the individual and combined prophylactic effects of Vitamin C (Vit C) and Coenzyme Q10 (CoQ10) against inflammatory heart injury in a cecal ligation and puncture (CLP) induced polymicrobial sepsis rat model.

Oxidative and antioxidative status in cardiac tissue
Antioxidant enzyme levels in cardiac tissue

The analysis of antioxidant and oxidant parameters in various experimental groups revealed significant differences in TAS levels (Fig. 2). Notably, the group subjected to CLP-induced sepsis exhibited a marked reduction in TAS compared to the control group, indicating a significant oxidative impact due to sepsis. In contrast, treatments with Vit C and CoQ10 showed a restorative effect on TAS levels, with CoQ10 displaying a slightly more pronounced improvement than Vit C alone. Most notably, the combination of Vit C and CoQ10 effectively restored TAS levels to nearly those observed in the control group.

The analysis of GSH levels demonstrated a significant decrease in the CLP group compared to the control group (p?<?0.001), underscoring the oxidative damage induced by sepsis. Individual treatments with Vit C and CoQ10 led to slight, but statistically significant, improvements in GSH levels (Vit C: p?<?0.05; CoQ10: p?<?0.05). However, the combined treatment of Vit C and CoQ10 resulted in a remarkable restoration of GSH levels, closely matching those of the control group (p?<?0.001).