TBK-1 enzyme - switches fat storage (to fat burning when inhibited)

Focus on Hong Kong Dr. Leung's vitamin B5 discovery that megadoses of pantothenic acid maintain metabolism of a calorie deficit, leading to sustained weight loss without hunger, weakness or ketosis

Moderators: ofonorow, popnowlin

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 13139
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

TBK-1 enzyme - switches fat storage (to fat burning when inhibited)

Post Number:#1  Post by ofonorow » Sat Feb 09, 2019 7:33 am

There is an interesting tidbit in Julian Michaels book 6 Keys... Something called TBK-1
https://www.medicalnewstoday.com/articles/320848.php

The TBK-1 enzyme is a burn fat/store fat switch. When inhibited, fat is burned.

Its interesting because the researchers found an old Asthma drug (developed in Japan, and no longer available in the USA) called amlexanox inhibits TBK-1, and thus induces fat burning! The drug is an anti-inflammatory drug, and in theory, you could take it while you needed to burn fat, and then stop :-)

Wiki says discontinued in the USA https://en.wikipedia.org/wiki/Amlexanox and has a tradename of Aphthasol. The wiki said the drugs was administered topically.

Strange that the drug would be taken off the market.. I remember something like this when vitamin K2 was found to be anti-cancer, it to was removed from the marketplace.

Another story
https://www.sciencedaily.com/releases/2018/02/180208141245.htm that discusses amlexanox.

Canker sore drug helps mice lose weight without diet, exercise
https://www.cnn.com/2013/02/10/health/mice-weight-loss-drug/index.html

During the search, happened to notice this news that there is now a way to triple the effectiveness of Lipase, the enzyme that breaks down fats so they can be metabolized... For future reference.


https://www.forbes.com/sites/melaniehaiken/2012/08/24/big-weight-loss-news-scientists-discover-switch-that-turns-on-fat-burning-enzymes/#2f48b2bd140a
Owen R. Fonorow, Follow #OWENRFONOROW at twitter

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 13139
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Re: TBK-1 enzyme - switches fat storage (to fat burning when inhibited)

Post Number:#2  Post by ofonorow » Sun Feb 10, 2019 7:56 am

There are some very interesting aspects to inhibiting the TBK1 enzyme, for example:

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
https://www.nature.com/articles/s41598-018-33875-0
Owen R. Fonorow, Follow #OWENRFONOROW at twitter

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 13139
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Re: TBK-1 enzyme - switches fat storage (to fat burning when inhibited)

Post Number:#3  Post by ofonorow » Tue Feb 12, 2019 8:35 am

The drug has been removed by our friends at the FDA, yet research persists. We are looking for a natural analog..

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.
https://www.ncbi.nlm.nih.gov/pubmed/30082428
Despite improvements in the in vitro potency, no analog produced a greater response in adipocytes than amlexanox, perhaps because of altered absorption and distribution
Owen R. Fonorow, Follow #OWENRFONOROW at twitter


Return to “Orthomolecular Weight Loss”

Who is online

Users browsing this forum: No registered users and 1 guest