Dose Dependent AA effect on insect model of Parkinsons
Posted: Sat Jul 14, 2012 4:39 am
Effect of L-ascorbic acid on the climbing ability and protein levels in the brain of Drosophila model of Parkinson's disease.
http://www.ncbi.nlm.nih.gov/pubmed/22776006
http://www.ncbi.nlm.nih.gov/pubmed/22776006
[lower doses had no effect] However, AA at 22.71×10(-5)M, 45.42×10(-5) M and 68.13×10(-5)M showed a dose dependent significant (P<0.05) delay in the loss of climbing ability of PD model flies as compared to the untreated PD flies.
The results suggest that AA is potent in delaying the climbing disability of the PD model flies expressing human alpha synuclein in the neurons.