Stroke Risk 70% Higher in Low Vitamin C Group

This forum will focus on analyzing recent clinical studies of vitamin C.

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Stroke Risk 70% Higher in Low Vitamin C Group

Post Number:#1  Post by ofonorow » Sun Dec 18, 2005 10:18 am

Strokes are evidence of cardiovascular disease in the brain.

There are generally two types of stroke. Either an artery becomes weak and then ruptures, or a blockage forms that prevents normal blood flow to parts of the brain. The Pauling/Rath unified theory predicts that arterial weakness, most often caused by insufficient vitamin C in the human diet, would lead to stroke, the 3rd or 4th leading cause of death in the United States.

There have been controlled and epidemiological studies that have found that low vitamin C predisposes one to having a stroke. A few of these studies are summarized here. There have also been studies that show high-antioxidants in the blood minimize the brain damage caused by a stroke.

The Ely observation on the value of CoQ10 in the prevention and healing of strokes is no doubt important, but hardly studied.

The following 2000 Japanese study found that the risk was 70% greater in the low vitamin C group.


In rural Japan, researchers examined a cohort of 880 men and 1,241 women ages 40 and older who were initially free of stroke when examined in 1977. Baseline examination included a measurement of serum vitamin C concentration. Incidence of stroke was determined by annual follow-up examinations. During the 20-year observation period, 196 strokes occurred, including 109 cerebral infarctions, 54 hemorrhagic strokes, and 33 strokes of undetermined type. The risk of stroke was 70% higher among those in the lowest quartile for serum vitamin C than among those in the highest.

The next study 2002 study found that the risk of stroke more than doubled in the low vitamin C group.

Plasma vitamin C modifies the association between hypertension and risk of stroke. (2002) ... t=Abstract

As summarized in this story: ... oryid=3720

Abstract wrote:RESULTS: Men with the lowest levels of plasma vitamin C (<28.4 micromol/L, lowest quarter) had a 2.4-fold (95% CI, 1.4 to 4.3; P=0.002) risk of any stroke compared with men with highest levels of plasma vitamin C (>64.96 micromol/L, highest quarter) after adjustment for age and examination months. An additional adjustment for body mass index, systolic blood pressure, smoking, alcohol consumption, serum total cholesterol, diabetes, and exercise-induced myocardial ischemia attenuated the association marginally (relative risk, 2.1; 95% CI, 1.2 to 3.8; P=0.01). Adjustment for prevalent coronary heart disease and atrial fibrillation did not attenuate the association any further. Furthermore, hypertensive men with the lowest vitamin C levels (<28.4 micromol/L) had a 2.6-fold risk (95% CI, 1.52 to 4.48; P<0.001), and overweight men (> or =25 kg/m2) with low plasma vitamin C had a 2.7-fold risk (95% CI, 1.48 to 4.90; P=0.001) for any stroke after adjustment for age, examination months, and other risk factors. CONCLUSIONS: Low plasma vitamin C was associated with increased risk of stroke, especially among hypertensive and overweight men.

The Following Dutch study looked at vitamin C intake from studying the diet. Although probably less accurate, this study too found an association between vitamin C intake and stroke. Note the low amounts of vitamin C.

This Dutch study is summarized here

Vitamin C May Ward Off Stroke ... 15972.html

A Dutch study finds people with the lowest amount of vitamin C in their diets were 30 percent more likely to have a stroke than people with the highest amount of it.

People with the highest amount of vitamin C in their diets consumed more than 133 milligrams of vitamin C per day. People with the lowest amount in their diets got less than 95 milligrams per day. The recommended daily amount is 60 milligrams a day.

The following studies indicate that maintaining high level of antioxidants may reduce brain damage after a stroke. (Note: mice and rats already make their own vitamin C.)

Vitamin C Derivative Prevents Stroke Damage in Mice ... trokes.htm

Antioxidant-rich diets reduce brain damage from stroke in rats ... wsid=22718

USF/VA neuroscientist Paula Bickford, PhD, and colleagues found that rats fed diets preventatively enriched with blueberries, spinach or an algae known as spirulina experienced less brain cell loss and improved recovery of movement following a stroke.

The study builds upon previous USF/VA research showing that diets enriched with blueberries, spinach or spirulina reversed normal age-related declines in memory and learning in old rats.

"I was amazed at the extent of neuroprotection these antioxidant-rich diets provided," said Dr. Bickford, a researcher at the USF Center for Aging and Brain Repair and James A. Haley Veterans' Hospital. "The size of the stroke was 50 to 75 percent less in rats treated with diets supplemented with blueberries, spinach or spirulina before the stroke."

COQ10 and Stroke

Dr. Ely informs us that CoQ10 under scientific analysis performed better than any (patentable) drug.

John Ely wrote:We report an unexpected favorable recovery from a complicated cerebral hemorrhage that is consistent with the remarkable results obtained for animal models of stroke using coenzyme Q10, reported to be far superior to all other substances tested (3,4). Gerbil survival to 40 days following carotid ligation induction of ischemic stroke, was 45% on Q10, over twice the 20% on naloxone, the second best agent tested (no deaths occurred after day 4 and the experiments were terminated at day 40). Such recoveries are not implausible since Q10's exceptional antioxidant and free radical quenching properties have been cited as offering "great implications in the treatment of IRI"(5).

The following case report is of a human taking large amounts of CoQ10 prior to her stroke. After her coma, to her doctor's amazement, she experienced no brain damage.

Hemorrhagic Stroke in Human Pretreated with Coenzyme Q10: Exceptional Recovery as Seen in Animal Models

In 26 years of animal model stroke studies, one substance that afforded a markedly higher degree of protection than all others tested was a normal endogenous molecule, coenzyme Q10 (Q10). Because of increasing worldwide use of Q10, we are able serendipidously to report on possibly the first observation of a human recovering almost completely from an unexpected cerebral hemorrhage following four weeks of pretreatment with Q10 at a pharmacologic dose commonly employed for a wide variety of disorders.

Infantile Scurvy

Sadly, as the population generally gets more ignorant, (a function of less and generally poor nutritional advice in the media), parents aren’t being told how important vitamin C and other antioxidants are for their children. The result is the increase in childhood stroke which we attribute to infantile scurvy.

Rate of childhood strokes has doubled: study ... hub=Health
Owen R. Fonorow, Orthopath® (Orthomolecular Naturopath)
® is a trademark of the Institute for Orthomolecular Studies

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