Higher Vitamin C Intake Lowers Risk of Gout

This forum will focus on analyzing recent clinical studies of vitamin C.

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Seymore Spectacles

Higher Vitamin C Intake Lowers Risk of Gout

Post Number:#1  Post by Seymore Spectacles » Tue May 13, 2008 1:45 pm

Vitamin C Intake and Serum Uric Acid Concentration in Men.

Gao X, Curhan G, Forman JP, Ascherio A, Choi HK.

From the Department of Nutrition and Department of Epidemiology, Harvard University School of Public Health; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; and Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA; and Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

OBJECTIVE: We examined associations between vitamin C intake and serum uric acid in men in a population-based study.

METHODS: We included 1387 men without hypertension and with body mass index (BMI) < 30 kg/m(2) in the Health Professional Follow-up Study. Dietary intake was assessed with a semiquantitative food frequency questionnaire validated for use in this population. Serum uric acid concentrations were measured.

RESULTS: Greater intakes of total vitamin C were significantly associated with lower serum uric acid concentrations, after adjustment for smoking, BMI, ethnicity, blood pressure, presence of gout, use of aspirin, and intake of energy, alcohol, dairy protein, fructose, meat, seafood and coffee.

An inverse dose-response association was observed through vitamin C intake of 400-500 mg/day, and then reached a plateau. Adjusted mean uric acid concentrations across total vitamin C intake categories (< 90, 90-249, 250-499, 500-999, or >/= 1000 mg/day) were 6.4, 6.1, 6.0, 5.7, and 5.7 mg/dl, respectively (p for trend < 0.001).

Greater vitamin C intake was associated with lower prevalence of hyperuricemia (serum uric acid > 6 mg/dl). Multivariate odds ratios for hyperuricemia across total vitamin C intake categories were 1 (reference), 0.58, 0.57, 0.38, and 0.34 (95% CI 0.20-0.58; P for trend < 0.001). When we used dietary data, which were assessed 4-8 years before blood collection, as predictors, we observed similar inverse associations between vitamin C intake and uric acid.

CONCLUSION: These population-based data indicate that vitamin C intake in men is inversely associated with serum uric acid concentrations. These findings support a potential role of vitamin C in the prevention of hyperuricemia and gout.

http://www.ncbi.nlm.nih.gov/pubmed/1846 ... d_RVDocSum

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Re: Higher Vitamin C Intake Lowers Risk of Gout

Post Number:#2  Post by ofonorow » Wed May 14, 2008 10:11 am

Which is contrary to medical dogma, but confirms my own personal experience. Again, thank you for find this.

My gout did not disappear after I began 3000 mg daily in 1983, but did go away never to return after I increased by C intake to 18,000 mg in 1986
Owen R. Fonorow, Orthopath® (Orthomolecular Naturopath)
® is a trademark of the Institute for Orthomolecular Studies

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