I already wrote the goal with bowel-tolerance over a day is to absorb the maximum of AA orally possible. Since it is for 99.9% of experimenters easier to do that in smaller doses more often, then it is for 99.9% of cases better over the other (of course I'm making this number up, untill now I haven't met even 1 person who tolerates higher doses better than a smaller dose..).
If you reacting for whatever unknown reasons differently and are therefore the 0.1% outlier, then of course try to do whatever you need to do to reach the goal of maximum AA absorbtion possible during a day. Thought that self-explanatory, therefore didn't answered any further.