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The DSMB also noted "a small and unexplained increase" in ischemic stroke rates in the Niaspan group. During the 32-month follow-up period, there were 28 strokes (1.6 %) reported during the trial among participants taking the Abbott drug versus 12 strokes (0.7 %) in the control group. However, the NIH stresses that "previous studies do not suggest that stroke is a potential complication of niacin, and it remains unclear whether this trend in AIM-HIGH arose by chance".
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