Re: Bioavailability of Vitamin C
Posted: Wed Jul 01, 2015 10:03 am
Hi Owen,
Briefly:
Cell membranes allow very small, non-polar, and lipid soluble molecules to pass.
The stomach is (or should be) strongly acid (HCl).
Weak organic acids are thus driven by the strong acid into the associated and relatively non-polar state (i.e. H+ A- becomes HA).
Thus small weak organic acids are often absorbed well in the stomach. In other words it is quite possible that vit C is absorbed in the stomach - and the extent depends on how polar is the 'associated molecule' etc..
Try this link to a section in a toxicology book which gives more detail:
https://books.google.co.uk/books?id=hWDNBQAAQBAJ&pg=PA619&lpg=PA619&dq=absorption+of+weak+organic+acids+stomach&source=bl&ots=Es-VCyEbGA&sig=0hNy7ft6Ywm0nTQSyucgBiZoEnM&hl=en&sa=X&ei=-SWUVbiYE4X8UqO7rjg&sqi=2&ved=0CDsQ6AEwAw#v=onepage&q=absorption%20of%20weak%20organic%20acids%20stomach&f=false
I hope the link works for you.
Steve
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30 minutes prior to the IV we did baseline measurements from each meter
A 134 mg/dl
B 120 mg/dl
C 120 mg/dl
Then after the IV was hooked up, but prior to the drip we did another baseline.
A 124 mg/dl.
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The following are the measurements every minute
Meter Minute Reading
A +1 147
B +2 143
C +3 143
A +4 152
B +5 146
C +6 152
A +7 159
B +8 150
C +9 162
A +10 159
B +11 164
C +12 159
A +13 168
B +14 164
C +15 174
A +16 162
B +17 167
C +18 173
A +19 179
B +20 174
C +21 178
A +22 175
B +23 187 ** New Test Strips
C +24 189
A +25 187
B +26 199
C +27 191
A +28 211
B +29 207
C +30 200
A +31 207
B +32 198
C +33 210
A +34 210
B +35 199
C +36 200
A +37 197
B +38 191
C +39 194
A +40 184 ** stopped IV (had slowed down tube for the past few minutes)
B +41 195
C +42 178
A +43 163
B +44 181
C +45 182
A +46 183
Paused measurement
B +50 177
C +54 164
A +58 167
B +80 165
all meters seemed to increase the score 10+ points with new test strips.
ofonorow wrote:Today I had a 10 gram (11.3 grams of sodium ascorbate) infused intravenously in 40 minutes.
ofonorow wrote:Note: Last time (gulping ascorbic acid) there was this quick spike and drop off, making us think that insulin may have spiked. Maybe I simply am insulin resistant or not making enough insulin?