Anyway, I take it 1.5 mg/dl is roughly equivalent to 70 umol/l.)
http://www.encognitive.com/files/Pharmacokinetics%20of%20oral%20vitamin%20C.pdf%20%20Seems%20to%20challenge%20the%20assertion%20of%20a%20maximum
Good paper and indicates that we can raise and sustain blood levels around 440 umol/l, or about double what the NIH predicted, enough to have a possible therapeutic effect on some cancers, and provides an argument for the sustained and continual intake of vitamin C throughout the day.
I found the second paper difficult to read and tried your trick - read conclusion first.
http://prhsj.rcm.upr.edu/index.php/prhs ... view/13/11
In general, the metabolism of ascorbate has been reported to be saturable. This conclusion comes from the observation of an upper limit to the rate of excretion of ascorbate metabolites as the oral dose of vitamin C is increased. However, re-analysis of the relation between the metabolite excretion rate and plasma ascorbate concentration indicates that this ratio remains essentially constant and that there is no saturation of ascorbate metabolism (47)
http://injectablevitaminc.com/images/Ch33.pdf
This 2004 paper seems diametrically opposed to the first, and second, and seems to be what the people doing the studies at Kansas believe - that oral intakes are tightly controlled. Only IV/C can raise blood levels, etc.
http://advances.nutrition.org/content/2/2/78.full.pdf
Again the idea seems to be IV over oral.
I am trying to figure out what happens to 9000 mg of ascorbic acid if I take it all at once by mouth.
I have been assuming that because I personally do not suffer runs, gas or diarrhea at this dose, that most (if not all) of the AA has been absorbed into the blood stream.
And I wonder if there is any delay or timed release action, say over several hours, that makes oralmore optimal than a high dose IV (bolus?) The IV quickly shoots its wad, but then the high blood levels are quickly excreted by the kidneys? Might not the slower oral dosage, in fact, be more "available" to tissues?
Knowing how much blood volume there is typically in the human body, and with our ability to crudely measure AA levels (above glucose), might we be able to predict what the glucose readings should be if 9000 mg of AA is taken orally? (One thought is to measure 9000 mg IV as the reference point)