Apologies for the long silence!
Still on my regime, nothing really changed except:
I drink about 8ml of 60% DMSO with my first and last dose of PT.
I uses a 50:50 mix of ascorbic acid and sodium ascorbate powder for my vitamin C. This reduces the sour taste, and is a bit better for my teeth.
I still plan to get a carotid ultrasound scan this year, but it is not so easy in the current stupid COVID environment.
Interesting data on palm oil - stuff that is extremely difficult to avoid. Palm oil major constituents are:
Palmitic acid 44% (a saturated fat)
Oleic acid 37%
Linoleic acid 9%
Palmitate, stearate and oleate are the most abundant Free Fatty Acids (FFAs) in the body.
Excess FFA critically induces reactive oxygen species (ROS) generation, resulting in lipotoxicity associated with ER stress, calcium dysregulation, mitochondrial dysfunction and cell death.Accumulating evidence supports a synergistic effect between palmitate and high glucose leading to diabetic complications.
mitochondrial DNA damage is observed as early as 48 h when bovine retinal cells are exposed to palmitate and high glucosehttps://www.nature.com/articles/emm2016157We demonstrated that PA induces lipid accumulation, mitochondrial injury, and apoptosis in podocytes. The mitochondria-mediated apoptotic pathway, rather than the death receptor pathway, is the main pathway involved in PA-induced apoptosis in podocytes, and excessive ROS production derived from damaged mitochondria is a key underlying mechanism.https://www.karger.com/Article/FullText ... ed/1614054Oleate Prevents Palmitate-Induced Atrophy via Modulation of Mitochondrial ROS Production in Skeletal Myotubeshttps://www.hindawi.com/journals/omcl/2017/2739721/
There is oleic acid in palm oil, but taking more oleic acid more (say by taking olive oil) would certainly offset the bad effects of palmitic acid.
Also, there is this 'antdote' :Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stresshttps://www.sciencedirect.com/science/a ... 4115002962
So olive oil and astragalus extract help.
I now take a tablespoon of olive oil per day and a 1/3 teaspoon of astragalus extract powder twice per day.