lp(a) down but bloodwork showing plac Lp-PLA2 tripled

The discussion of the Linus Pauling vitamin C/lysine invention for chronic scurvy

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gmdodaro
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lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#1  Post by gmdodaro » Mon Nov 17, 2014 10:29 pm

I have been diligently applying vitamin C + lysine + proline in recommended proportions for about six weeks. Today I got the results of recent blood work. My doctor and I are so perplexed we are going to repeat the tests. There are a couple of anomalies. Maybe somebody on this forum can explain the reason for Lp-PLA2 tripled to 637. I had to do this discussion with my doctor by phone because I'm out of town for a couple of weeks, so I don't have the printed results in hand, but the doctor has never seen anything like it. My previous Lp-PLA2 numbers were a little high, but not alarming. Maybe I'm releasing plac from my arteries and it is circulating in the blood. That would be the positive way to look at it. We don't have enough experience with Pauling therapy to compare these results to anybody else. My previous lp(a) number was 23, and it went down to 19. Great! But the Lp-PLA2 number is disturbing. hs-CRP < 1
Last edited by gmdodaro on Wed Nov 19, 2014 9:40 am, edited 5 times in total.

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Re: lp(a) down but bloodwork showing plaque over 2000

Post Number:#2  Post by ofonorow » Tue Nov 18, 2014 1:48 pm

Please explain. What is a "plaque" number?
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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#3  Post by gmdodaro » Tue Nov 18, 2014 2:37 pm

Now that I have the results by email, I have modified the original post with correct information about Lp-PLA2, which tripled since my last test in June 2014. The current number is 637 is still disturbing because the reference range top is 199.
The number 2064 is ferritin, which is way out there. Top of reference range is 450, and I've been hoping to bring my previous reading of 377 down under 100. This is likely a result of the chelation I've been doing, not Pauling Therapy. Same rationalization: I've been pulling iron out and it can only go into circulation as bound iron. I'm going to have to find a way to get it down. Giving blood is the usual remedy, but I have thalassemia and my hematocrit is usually just below acceptable standard for blood banks.

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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#4  Post by ofonorow » Wed Nov 19, 2014 10:43 am

I am interested in johnwen's thoughts as I have never heard of the Lp-PLA2.

However from wikipedia - it is an enzyme not a cholesterol.
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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#5  Post by Johnwen » Wed Nov 19, 2014 4:26 pm

This sounds like a serious case of inflammatory reaction going on somewhere with in this person and his doc really needs to get off his duff and get him in and checked out.
Usually with levels of ferritin and LP-Pla2 (PLAC test) both being high there is a SERIOUS inflammation problem going on which could range from Rheumatoid arthritis to Systemic lupus erythematosis! If it was an ongoing thing with them it could be a gene problem this rise could be caused by Sideroblastic Anemia.
But a sudden onset means there’s a big problem brewing and he need’s attention NOW! RED FLAGS WAVING ALL OVER THE PLACE!!!!!
If his doc wants to do a Re-test Make sure he includes a hs-CRP test to confirm the other references.

Best advice I could give is DON’T WAIT your risk of a stroke with this is up there with the stars!
NO Alcohol what so ever, either!
Act NOW!
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research!

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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#6  Post by gmdodaro » Wed Nov 19, 2014 5:03 pm

There was hs-CRP In this bloodwork: hs-CRP < 1.
I've talked with two doctors and am consulting a third. Second opinion is that the high ferritin may be driving the inflammation. I've scheduled phlebotomy on advise from both doctors to get rid of some iron.

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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#7  Post by ofonorow » Thu Nov 20, 2014 7:24 am

Regarding general health, and considering what johnwen said, do you have pain in other parts of the body, especially joints, toes and knuckles?

If so, you should try and get a saliva all-day cortisol test (even though orthodox doctors don't accept them) and see where your cortisol is at.

Levy and others have a protocol for lowering ferritin - the only supplement I remember of the top of my head is IP-6.
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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#8  Post by gmdodaro » Thu Nov 20, 2014 10:00 am

No other pain in joints or anywhere. I've been feeling fine. I read Levy and ordered the IP6. Took out 90 cc blood yesterday and did another ferritin test. Results should be back today.
hs-CRP < 1. Some consolation right now.

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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#9  Post by gmdodaro » Sun Dec 14, 2014 8:10 pm

Investigation of the radical spike in my ferritin, which turned out to be accompanied by spikes in liver enzymes, led to ultrasound on my liver, and further testing. The lab results have been diagnosed as the result of an active infection of hepatitis C. Viral load confirms it, not high, but significant at about 380,000 rna IU/ml. Over the past month I've been treated by a naturopath using phlebotomy, R alpha lipoic acid, N acetyl cystine, and a few others.

I consulted a doctor, board certified in thalassemia, trying to determine if vitamin C was affecting iron load, because vitamin C is used to increase iron availability for chelation by deferoxamine. Inconclusive... . Still waiting for appointment with infectious disease specialist to explore conventional treatments for hepatitis C.

Due the possible effects of vitamin C on thalassemia induced iron overload, I reluctantly reduced vitamin C supplementation and continued with the phlebotomies, R alpha lipoic acid etc. The result are encouraging, so I have started adding more vitamin C to the regimen. Drs Levy and Cathcart both recommend high dose vitamin C for hepatitis C.

A month ago my ferritin reached 4107
Liver enzymes also tested very high:
Alkaline phosphatase: 164
Alkaline Aminotransferase: 1785
Aspartate Aminotranserase: 1083
Bilirubin total: 4.3

Hence the trip to the hospital for ultrasound on my liver, which showed no damage yet.

Based on the above lab results, the naturopath did phlebotomy almost daily, being careful with my thalassemia induced anemia so my hematocrit and hemaglobin haven't gone too low. He suggested a heptatitis C treatment protocol following Dr. Bert Berkson: http://www.healthyhepper.com/berksonclinicalstudy.htm . A couple of weeks of this have shown considerable improvement. I may still have to endure months of drug treatments, but my labs are much improved:

Ferritin: 1053
Alkaline phosphatase: 139
Alkaline Aminotransferase: 674
Aspartate Aminotranserase: 395
Bilirubin total: 3.0

This press release is the best thing I've seen from conventional medicine on hepatitis C: http://www.eurekalert.org/pub_releases/ ... 041014.php

One of these days I'd like to get back to reducing my coronary calcium, Lp(a), and Lp-PLA2 . Fortunately because I was getting labs frequently for heart disease, I saw the ferritin spike early and discovered the liver enzymes were also way off. Difficult to say how long the hepatitis C virus has been in my system. I've never had a transfusion, don't do drugs, and I'm not homosexual. I worked for ten years as a dialysis tech doing punctures and working with blood, so that is the only likely source of my infection.

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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#10  Post by Johnwen » Mon Dec 15, 2014 10:39 am

I worked for ten years as a dialysis tech doing punctures and working with blood, so that is the only likely source of my infection.


What’s that old saying “BINGO!”

Hep C is a nasty bugger it’s probably the most opportunistic virus’s out there and only takes a micron size drop of blood to make it’s entrance.

I for one am glad you listened and looked in to it. Hopefully your early enough before it started doing some real damage which is what things sound like to me right now. Your body is putting up a pretty good fight so make sure you get the nourishment and medical care to support it’s battle.

Here’s the complete report on that news release. It’s a PDF file:

http://www.gastrojournal.org/article/S0016-5085(14)00603-9/pdf

Good Luck and keep us posted on your progress!
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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#11  Post by gmdodaro » Mon Dec 15, 2014 6:02 pm

Thanks Johnwen.

The labs on my liver enzymes are continuing to move in the right direction:
Numbers from two previous weeks:
Alkaline phosphatase: 139 -> 120
Alanine Aminotransferase: 674 -> 386
Aspartate Aminotranserase: 395 -> 178
Bilirubin total: 3.0 -> 2.4

This week I want to get the ferritin measured and do the viral load test again.
Now I have an appointment with an infectious disease specialist who can give me information about conventional treatments for hepatitis C. I am very curious to see what she will say about the improvements I've seen on the Bert Berkson regemin: R ALA + selenium + silymarin.

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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#12  Post by gmdodaro » Sun Feb 08, 2015 11:49 pm

Just for the record, this treatment, http://www.healthyhepper.com/berksonclinicalstudy.htm , by naturopath Michael Conway in Vancouver, WA has put hepatitis C in remission. My liver enzymes are back to normal and ferritin last measured at 214, down from 4000+. Viral load was undetectable for last two measurements. It took about two months and also included phlebotomy to bring down the iron.

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Re: lp(a) down but bloodwork showing plac Lp-PLA2 tripled

Post Number:#13  Post by gmdodaro » Tue May 10, 2016 2:47 pm

Just for the record, my hepatitis C viral load has been undetectable since February 2014. The Berkson treatment works. The costs are negligible compared to Solvadi or other hepatitis C drugs priced in excess of $100 per day. My consultations with a conventional doctor, who said she had treated hepatitis C for 30 years, led to her recommendation for a liver biopsy and the finding that medical insurance does not cover hepatitis C until the patient is stage 3, which is on the verge of a liver transplant.


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