Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-α, and ROS production in Gulo(−/−)Vit C-Insufficient mice
Highlights
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Vitamin C insufficiency accelerates the stress-induced death of Gulo(−/−) mice.
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Oxidative stress in the heart is increased by stress and vitamin C insufficiency.
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TNF-α, ADR, and NA are excessively produced by stress and vitamin C insufficiency.
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Structural/functional cardiac changes are induced by stress and vitamin C insufficiency.
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Vitamin C supplementation prevents cardiac changes and death of Gulo(−/−) mice.
http://www.sciencedirect.com/science/ar ... 4913003675