Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms.

[ofonorow]

Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress.

Abstract

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Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6.
Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms.
Okuyama H1, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, Uchino H.
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Erratum. Correction to: Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. [Expert Rev Clin Pharmacol. 2015]

Abstract

In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and 'heme A', and thereby ATP generation. Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification. Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. Thus, the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs. We propose that current statin treatment guidelines be critically reevaluated.

[Johnwen]

Here's the full article in PDF

http://www.tandfonline.com/doi/pdf/10.1 ... 15.1011125

[blade]

the more I read about statins, the worse they are..are these useful for anyone?

[gizmo1955]

I recently stopped taking atorvastatin after about15 years of use. Can't say that I feel any different but I hope that it helps in the long run. I know when I discussed it with my GP he was not very happy about it (he doesn't need to be!) The next time I go see him I may take this report and show him to get his thoughts.

[lolex]

viewtopic.php?f=11&t=12375

This presentation is extremely interesting and informative http://www.youtube.com/watch?v=yX1vBA9bLNk (It's also quite humorous!!)

It's worth your time if you take Statins.... you'll stop them immediately after seeing this. I promise.

By the Author of "How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease" already referenced by Owen in this Forum and published in the Expert Review of Clinical Pharmacology

[ofonorow]

bump

[Johnwen]