high lpa, trying new drug

[TommyTurtle]

I tried Niacin before Lysine and Proline. Prior to any supplementation my Lp(a) levels were 610 mm/L

I trialled Niacin 1.5g plus Vit C 5.0g

After 10 weeks my Lp(a) dropped around 60% to 260 mm/L. Niacin can be very effective if you have low molecular weight Lp(a). Not effective for high molecular weight Lp(a). Best way to find out is by trialing.

Niacin is very cheap. Some people don't like the flushing, however it isn't dangerous. I'm expecting that the lowering of Lp(a) will assist in stopping progression of CVD. Now also supplementing with Lysine, Proline, Citrulline, Magnesium, K2, MSM

Very suspicious of Niacin trials conducted by pharma companies. They have a vested interest in debunking the effectiveness of Niacin. Their recent trials look at Niacin in conjunction with statins, not Niacin by itself (you actually don't need the statins). Previous trials of Niacin alone have established effectiveness for most people

I have dropped to 18% body fat, targeting 15% through increasing lean mass (i.e. Losing fat at same rate as building muscle). Fully agree with your advice re weight

I would avoid any new drug like the plague. They all have adverse side effects, often as bad as the disease or condition they are treating.

In addition to above I am increasing corollary heart circulation (creating additional blood vessels to nourish the heart) by high intensity interval training. Don't go crazy initially but build over time. The heart isn't just nourished by arteries alone but a myriad of blood vessels. Exercise assists in building supplementary blood supply so not dependent on a few arteries

There's stuff we can't control, so concentrate on what you can (which is plenty).

[pamojja]

[TommyTurtle]

I've had persistently high LDL levels all my adult life at around 220. Nothing has been able to reduce this (until revently). My triglycerides are very low at 26 and HDL positive at 84. Recently had subtraction test which showed virtually no small dense LDL present despite high reading. Supposedly if you have a good HDL to Trig ratio you won't have SD LDL particles present.

Upon commencement of 5g Lysine and 2.5g Proline my LDL levels dropped 23% to 170 but my Lp(a) rose slightly. It appears the Lysine or Proline is binding to LDL.

[pamojja]

That's been my Lp(a)s each half year during the last 7 years backwards (2016-2009) on about 23g vitamin C, 6g lysine and 2g proline for the last 8 years:

Code: Select all

51   -   34   36   59   34   43   -   46   64   66   52   46   48   57   -

<30 mg/dl range. Only a meager 11% improvement all these years. The better values always when serum DHEA and testosterone normalized.

However, also a 50% improvement with HDL, 47% in LDL and 28% with trigs, at the moment.

[pamojja]

Only a meager 11% improvement all these years.

Actually can't know for sure, because I had started with Pauling's therapy, other supplements and diet interventions well before testing it for the first time. It might have been much higher.

Im not following the "graph", but have you gotton estradiol 20-30pg/ml?

As said, the numbers go from left to right from 2016 each half year back to 2009. Thase are the values for estradiol:

Code: Select all

46   -   21   -   32   -   -   -   34   13   <10   -   51   -   -   -

Highly fluctuating, but the mean is at 29 pg/ml.

[TommyTurtle]

Pamojja, have you had heart attack or stroke? Do you know your Coronary calcium score?

[pamojja]

No heard attack or stroke. 'Just' a 80% blockage at my abdominal aorta bifurcation diagnosed as PAD 8 years ago, causing intermittent claudication (only a 3-400 meter pain-free walking distance) and a 60% government-certified disability due to this walking disability. With Pauling Therapy that improved very fast - 1hr after the first, 2 hrs the second, 1/2 hr due the a chronic bronchitis the third year, since then improving again, until in my 6th year it ceased - and have lost that disability again.

I never did a Coronary calcium since with that high a specific stenosis I had to consider myself in the highest risk-group for that condition anyway. And repeated scores would add to radiation-burden, while at the same time needing a good technician for consistent and therefore useful readings. Since CAC scores aren't routinely done for CVD where I live, that precondition wasn't a given.

Diagnosing cardiologists prognosed a 30% 5-year mortality despite all interventions they suggested, and I refused. Therefore I take being still alive 8 years later and getting better as my own kind of score..

[TommyTurtle]

That's a great success story Pamojja. You're empowered and defying the odds given by the traditional medical establishment

[guitarplayer007]

So Vitamin C therapy doesn't help reduce Lpa? My score last August was 59, the test says it should be under 30..I started Vitamin C therapy 5 weeks ago and having blood text in 2 weeks per cardiologist...He doesn't know I'm trying this protocol

[pamojja]

So Vitamin C therapy doesn't help reduce Lpa?

How you come to that conclusion? Because it didn't do in only one experience?

In science they usually do randomized controlled trials - RCT - to find the effectiveness of an agent. That means a randomly selected drug and control group get the drug or the inert placebo, without the scientist or study-participants knowing who is getting what. In the end they lift the blinding and compare how many got better or worse - with the drug tested against the placebo. Then for example maybe 10 got better in the drug group compared to 5 in the placebo group of a total of a 100 study participants. Would mean the drug is 100% better than placebo and will be marketed as such. Never mind either didn't help 85% of participants.

No agent helps all the time in all cases. That is just not how it works. Precondition are too various and multi-factorial. But that doesn't mean it couldn't in others. And there are indeed enough reports here where vitamin C lowered Lp(a). But without RCT we'll never know at what percentage.

[TommyTurtle]

The reason I take Vit C is to form strong & healthy arterial walls. Healthy arteries will prevent Lp(a) binding no matter what your level. Whilst it's a conjuctive strategy to also lower your Lp(a), it's not the main reason for Vit C therapy

[pamojja]

No heard attack or stroke. 'Just' a 80% blockage..

Wait a minute, just had a brain MRI for investigation of remaining symptoms like a ME/CFS, where they reported (Google translate):

Old infarction in the left cerebellum hemisphere mediobasal belonging to the current region of the cerebellar artery posterior inferior (6/40-44) from ap up to 3 cm, tranversal up to 1 <cm and craniokaudal scarcely 2cm size in each largest diameter. Otherwise, the structure and signal behavior of the brain are regular. Regular diffusion ratios. Symmetrical, medium, normal wide supra- and infratentorial ventricular system. The external CSF spaces are normal. Virchow-Rubin's rooms in the typical places. Discretely diverging axes of the bulbi oculorum with closed eyelids. Otherwise the orbits and their contents are regular. Individual delicate mucosal swellings in several ethmoidal cells on the left more pronounced than on the right, and extremely faint on the left forehead. The remaining nasal sinuses and temporal bones on both sides are properly signalless.

Since I'm not aware of any stroke symptoms - except some occasional vision disturbances between 1992-2006 (for some 20 minutes flickering like the visual snow of an off-line TV at the focus, followed by paresthesia mostly in tongue and parts of the face) - I assume it to have been caused by one of my 4 falciparum malarias (often ending in the dangerous cerebral malaria; 1994-1995), or a complication after a nitrogen intoxication after my only dive down to 40 meters (1995)?

Probably will never know for sure.

[pamojja]

are you on aromastate inhibitors, TRT, or just gained/lost fat?

No to all 4.

[Johnwen]

Pamojja;

Sounds more like a Aura from a migraine to me!

Next time you get it pop a Tylenol or aspirin and see if it goes away in about 10min.

[pamojja]

- except some occasional vision disturbances between 1992-2006 (for some 20 minutes flickering like the visual snow of an off-line TV at the focus, followed by paresthesia mostly in tongue and parts of the face) -

Pamojja;

Sounds more like a Aura from a migraine to me!

Next time you get it pop a Tylenol or aspirin and see if it goes away in about 10min.

Interesting, because since early childhood, when I had a lot of headaches, nowadays almost never. And rarely only the visual snow now. When it's recurring I'll try a aspirin I've around.

This started to happen when I was vegetarian in 3rd world countries for long times - where in available restaurants mainly meat was available - and me therefore on very restricted diets (like beans and tortillas or rice only), I rather suspected a deficiency.