What type of apo-a should be measured?

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Frodo
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What type of apo-a should be measured?

Post Number:#1  Post by Frodo » Sun Nov 04, 2018 5:25 am

Owen

According to Pauling/Rath lp(a) is a ldl particle which is surrounded by the sticky protein apo-a.

What kind of apo-a is that?

The laboratory writes: apo-a1 is a protective factor against atherosclerosis and occurs predominantly in hdl. I thought, that‘s good. My apo-a1 value is high and my hdl also. Is that right?

Apo-a2 is the transporter for phospholipides.

Apo-a3 is contained in vldl, ldl and hdl.

And apo-b especially in ldl.

What type of apo-a should be measured - additional to lp(a)?

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Re: What type of apo-a should be measured?

Post Number:#2  Post by ofonorow » Sun Nov 04, 2018 6:56 am

There is a confusion, in that little a and capital A refer to different proteins. I have never heard of "a1" and assume this refers to A1... Here is a list of all the "capital" lipoprotiens https://en.wikipedia.org/wiki/Apolipoprotein

I could be wrong about this, but here is the definition of Apo(A)


Apolipoprotein A
Apolipoprotein A makes up about 90% of the proteins in high density lipoprotein (HDL). So if you have a deficiency in apo A you will also have a deficiency in HDL. The levels of different types apolipoprotein A is important in controlling heart disease. Increased levels of apo A5 leads to increased triglyceride levels while apo A1 works with apo E to reduce triglyceride levels.

https://study.com/academy/lesson/apolipoproteins-function-structure-types.html


Notice apo(A) is associated with HDL, while Lp(a) is associated with LDL.

Notably neither wiki page, or the following web page mentions "little a" ...

Science direct on lipoprotiens https://www.sciencedirect.com/topics/neuroscience/apolipoproteins

I am speculating, but I would think the special designation Lp(a) was to separate it from apo(A) and the only reference I've see with apo(a) (without Lp(a)) was in the Pauling/Rath guinea pig experiments. I think apo(a) in humans always binds to an LDL (of varying size and density) and so in humans, the measurement you want is Lp(a).
Owen R. Fonorow
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American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year

Frodo
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Re: What type of apo-a should be measured?

Post Number:#3  Post by Frodo » Sun Nov 04, 2018 7:32 am

Thanks Owen,
you are right. It‘s the difference between „apo-a“ and „apo-A1 (and so on)“. And I measured my apo-A1 value. It was high and that is really good. (Now I‘ve understood).
My lp(a) is still unchanged (157 nmol/l; ref. value: <75).

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Re: What type of apo-a should be measured?

Post Number:#4  Post by Johnwen » Mon Nov 05, 2018 10:39 am

See if you can understand how this works!
Read the links also Highlighted in blue, it may help! :D

https://en.wikipedia.org/wiki/Chylomicron


Now for LP(a) here’s a wealth of knowledge on it!

https://www.lipoproteinafoundation.org/ ... erstandLpa
To steal ideas from one person is plagiarism. To steal from many is
research!


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