New Method for Very High Potency Liposomal Vitamin C

Discussion of the benefits and disadvantages of commercial and homemade (DIY) liposomal vitamin C

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Jacquie
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Re: New Method for Very High Potency Liposomal Vitamin C

Post Number:#196  Post by Jacquie » Sun Apr 19, 2020 7:36 am

donw146 wrote:Hi everyone. Like the last poster to this thread from 2018 I'm new to this forum and Liposomal Vitamin C. I stumbled across the subject while reading coronavirus articles and hoped I had found something that could help. I'm planning on making the recipe described by qualityliposomalc using the following variations:
1. Blender only (I don't have an ultrasonic cleaner and they're very expensive to buy in Canada).
2. Vodka
3. NOW brand ascorbic acid and sunflower lecithin powder.
I noticed that Step 2 of the process says "It is important that mixture is nicely warm to touch as this ensures that the lecithin granules have melted and avoids any chance of separation." I would prefer to be more precise about the temperature. Some searches I ran on "transition temperature" suggested that the temperature should be raised to about 45 - 49°C. I hope that some of you can comment on this.


120 degrees F seems far too warm to my memory of making lipsomal C at home. I believe that temperature would destroy a certain amount of your vitamin c before it gets encapsulated. If I recall correctly, I heated the mixture to 95 degrees F, or 35 C.

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Re: New Method for Very High Potency Liposomal Vitamin C

Post Number:#197  Post by BrightSideOfLife » Thu Apr 23, 2020 11:24 pm

Jacquie wrote:
donw146 wrote:Hi everyone. Like the last poster to this thread from 2018 I'm new to this forum and Liposomal Vitamin C. I stumbled across the subject while reading coronavirus articles and hoped I had found something that could help. I'm planning on making the recipe described by qualityliposomalc using the following variations:
1. Blender only (I don't have an ultrasonic cleaner and they're very expensive to buy in Canada).
2. Vodka
3. NOW brand ascorbic acid and sunflower lecithin powder.
I noticed that Step 2 of the process says "It is important that mixture is nicely warm to touch as this ensures that the lecithin granules have melted and avoids any chance of separation." I would prefer to be more precise about the temperature. Some searches I ran on "transition temperature" suggested that the temperature should be raised to about 45 - 49°C. I hope that some of you can comment on this.


120 degrees F seems far too warm to my memory of making lipsomal C at home. I believe that temperature would destroy a certain amount of your vitamin c before it gets encapsulated. If I recall correctly, I heated the mixture to 95 degrees F, or 35 C.

Liposomes will not form at 35C because the transition temperature does not occur with Lecithin below 43C. If you do not reach the transition temperature then you do not form liposomes. The only alternative is to use a different form of phosphatidylcholine with a lower transition temperature. There are many different forms of PC but most are not easily available.

45C might be higher than absolutely necessary, ~43-44C might be enough. Ascorbic acid should be okay at that temperature. 49C is higher than necessary but is around the top end of the transition range.

Jacquie
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Re: New Method for Very High Potency Liposomal Vitamin C

Post Number:#198  Post by Jacquie » Fri Apr 24, 2020 8:13 am

BrightSideOfLife wrote:
Jacquie wrote:
donw146 wrote:Hi everyone. Like the last poster to this thread from 2018 I'm new to this forum and Liposomal Vitamin C. I stumbled across the subject while reading coronavirus articles and hoped I had found something that could help. I'm planning on making the recipe described by qualityliposomalc using the following variations:
1. Blender only (I don't have an ultrasonic cleaner and they're very expensive to buy in Canada).
2. Vodka
3. NOW brand ascorbic acid and sunflower lecithin powder.
I noticed that Step 2 of the process says "It is important that mixture is nicely warm to touch as this ensures that the lecithin granules have melted and avoids any chance of separation." I would prefer to be more precise about the temperature. Some searches I ran on "transition temperature" suggested that the temperature should be raised to about 45 - 49°C. I hope that some of you can comment on this.


120 degrees F seems far too warm to my memory of making lipsomal C at home. I believe that temperature would destroy a certain amount of your vitamin c before it gets encapsulated. If I recall correctly, I heated the mixture to 95 degrees F, or 35 C.


Liposomes will not form at 35C because the transition temperature does not occur with Lecithin below 43C. If you do not reach the transition temperature then you do not form liposomes. The only alternative is to use a different form of phosphatidylcholine with a lower transition temperature. There are many different forms of PC but most are not easily available.

45C might be higher than absolutely necessary, ~43-44C might be enough. Ascorbic acid should be okay at that temperature. 49C is higher than necessary but is around the top end of the transition range.


Your assertion contradicts the instructions on the website quoted on the first post of this thread. Do you have a source that backs up your claim for the higher temperatures being necessary?

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Re: New Method for Very High Potency Liposomal Vitamin C

Post Number:#199  Post by BrightSideOfLife » Fri Jul 31, 2020 12:35 am

Jacquie wrote:
BrightSideOfLife wrote:
Jacquie wrote:
120 degrees F seems far too warm to my memory of making lipsomal C at home. I believe that temperature would destroy a certain amount of your vitamin c before it gets encapsulated. If I recall correctly, I heated the mixture to 95 degrees F, or 35 C.


Liposomes will not form at 35C because the transition temperature does not occur with Lecithin below 43C. If you do not reach the transition temperature then you do not form liposomes. The only alternative is to use a different form of phosphatidylcholine with a lower transition temperature. There are many different forms of PC but most are not easily available.

45C might be higher than absolutely necessary, ~43-44C might be enough. Ascorbic acid should be okay at that temperature. 49C is higher than necessary but is around the top end of the transition range.


Your assertion contradicts the instructions on the website quoted on the first post of this thread. Do you have a source that backs up your claim for the higher temperatures being necessary?

Other things have occupied my time therefore I have not been able to reply until now. One of the problems with lecithin is that there is no standard because it contains different quantities of fatty acids which alters the transition temperature. I have come across something which seems related in that it shows temperature and ultrasonic energy applied time. I somehow doubt that you will like it because the temperature is fairly high.

Have a read and see what you think. OPTIMIZATION OF MIXING TEMPERATURE AND SONICATION DURATION IN LIPOSOME PREPARATION


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