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tjohnson_nb wrote:Also, since probably 10's of thousands of IV C treatments have been done over the years without any mention if these effects it doesn't seem like there is any connection to it.
tjohnson_nb wrote:I t seems to me that if someone got central pontine myelinolysis from IV Sodium Ascorbate then the doctors administering it would have noticed - it seems like an extremely debilitating condition. Perhaps it does not happen because there is not the initial condition of very low sodium in the first place?
jamesLdavis1 wrote:Has anyone explored the dangers of this condition in administering IV Sodium Ascorbate at high concentrations? It is a very serious complication
Central pontine myelinolysis is brain cell dysfunction caused by the destruction of the layer (myelin sheath) covering nerve cells in the middle of the brainstem (pons).
The most common cause of central pontine myelinolysis is a quick rise in the body's sodium levels. This most often occurs when someone is being treated for low blood levels of sodium (hyponatremia) and the sodium is replaced too fast. It also can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly.
This condition does not occur on its own. It is a complication of treatment for other conditions or from the other conditions themselves.
Outlook (Prognosis)
The nerve damage caused by central pontine myelinolysis is usually long-lasting. The disorder can cause serious long-term (chronic) disability.
Possible Complications
Decreased ability to interact with others
Decreased ability to work or care for self
Inability to move, other than to blink eyes ("locked in" syndrome)
Permanent nervous system damage
Via NLM.NIH.GOV
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