Telomere Length/Telomerase Studies

Discussion of the 2009 Noble Prize in Medicine, focusing on substances that reduce telomere shortening by activating the human telomerase enzyme

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Telomere Length/Telomerase Studies

Post Number:#1  Post by ofonorow » Thu Jan 22, 2015 9:31 am

http://www.ncbi.nlm.nih.gov/pubmed/9454332

Science. 1998 Jan 16;279(5349):349-52.
Extension of life-span by introduction of telomerase into normal human cells.
Bodnar AG1, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE.
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Abstract

Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that telomere shortening is the molecular clock that triggers senescence. To test this hypothesis, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomerase catalytic subunit. In contrast to telomerase-negative control clones, which exhibited telomere shortening and senescence, telomerase-expressing clones had elongated telomeres, divided vigorously, and showed reduced straining for beta-galactosidase, a biomarker for senescence. Notably, the telomerase-expressing clones have a normal karyotype and have already exceeded their normal life-span by at least 20 doublings, thus establishing a causal relationship between telomere shortening and in vitro cellular senescence. The ability to maintain normal human cells in a phenotypically youthful state could have important applications in research and medicine.
Owen R. Fonorow
HeartCURE.Info
American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year

blade

Re: Telomere Length/Telomerase Studies

Post Number:#2  Post by blade » Thu Jan 22, 2015 1:17 pm

how do we increase teleomere length?

ofonorow
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Re: Telomere Length/Telomerase Studies

Post Number:#3  Post by ofonorow » Fri Jan 23, 2015 7:31 am

Stay tuned :D
Owen R. Fonorow
HeartCURE.Info
American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year


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