Dr. Jekyll & Mr. Hyde: Telomere and Telomerase in Stem Cells

Discussion of the 2009 Noble Prize in Medicine, focusing on substances that reduce telomere shortening by activating the human telomerase enzyme

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Dr. Jekyll & Mr. Hyde: Telomere and Telomerase in Stem Cells

Post Number:#1  Post by ofonorow » Wed May 20, 2015 10:40 am

http://www.alphagalileo.org/ViewItem.aspx?ItemId=152887&CultureCode=en
Dr. Jekyll & Mr. Hyde: Telomere and Telomerase in Stem Cells

New look at an old debate.


In the adult human, the activity of telomerase is mostly restricted to the stem cells and is absent from the vast majority of human cells. In the absence of telomerase, telomere shortening limits cellular life span and prevents tumorigenesis. However, cells with too short telomeres can lose capping function leading to a cellular catastrophe and genetic instability: the origin of many cancer types. In this scenario, telomerase activity is protecting from tumor formation that can be initiated by these dysfunctional telomeres.
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