“Unexpected” Discovery in Anti-Aging Science Reveals Process that Lengthens Immune Cell Lifespan

Discussion of the 2009 Noble Prize in Medicine, focusing on substances that reduce telomere shortening by activating the human telomerase enzyme

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“Unexpected” Discovery in Anti-Aging Science Reveals Process that Lengthens Immune Cell Lifespan

Post Number:#1  Post by ofonorow » Thu Nov 10, 2022 10:13 am

https://thedebrief.org/unexpected-discovery-in-anti-aging-science-reveals-process-that-lengthens-immune-cell-lifespan/

Traditionally, it has been observed that white blood cells known as T-lymphocytes perform the function of activating telomerase, which delays the onset of a cell’s deterioration. In their paper, the team demonstrates that some T cells were able to lengthen telomeres “by acquiring telomere vesicles from antigen-presenting cells (APCs) independently of telomerase action.”

Once these T cells make contact with APCs, it instigates a degradation of a protein complex in the latter cells known as shelterin, which is thereby “donated” to telomeres after being removed by a telomere-associated protein known as TZAP, and thereafter carried in extracellular fluid sacks, or vesicles, to the synapses that form junctions between immunological nerve cells.
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