Efficacy of Vitamin C Supplementation on Chronic Obstructive Pulmonary Disease (COPD

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Efficacy of Vitamin C Supplementation on Chronic Obstructive Pulmonary Disease (COPD

Post Number:#1  Post by ofonorow » Sat Sep 10, 2022 8:28 am

Efficacy of Vitamin C Supplementation on Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis
https://www.dovepress.com/efficacy-of-vitamin-c-supplementation-on-chronic-obstructive-pulmonary-peer-reviewed-fulltext-article-COPD

From experience, I personally distrust meta-analysis, especially of vitamin C when the group of studies usually are of such small dosages, but this one found:

Results:

Ten RCTs including 487 participants were eligible for our study.

Meta-analysis results showed that vitamin C supplementation (≥ 400 mg/day) can significantly improve the forced expiratory volume in one second as a percentage (FEV1%) in COPD (SMD:1.08, 95% CI:0.03, 2.12, P=0.04). Moreover, vitamin C supplementation significantly improved the ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) (WMD:0.66, 95% CI: 0.26, 1.06, P=0.001), vitamin C level in serum (SMD:0.63, 95% CI: 0.02, 1.24, P=0.04) and glutathione (GSH) level in serum (SMD:2.47, 95% CI: 1.06, 3.89, P=0.0006). While no statistically significant difference was observed in body mass index (BMI), fat-free mass index (FFMI), vitamin E level and superoxide dismutase (SOD) level in serum.

Conclusion:

Vitamin C supplementation could increase the levels of antioxidation in serum (vitamin C and GSH) and improve lung function (FEV1% and FEV1/FVC), especially in patients treated with vitamin C supplementation greater than 400 mg/day. However, (he he - to get this published) further prospective studies are needed to explore the role of vitamin C in improving nutritional status.


Over the years we have had anecdotal reports at this forum of the efficacy of vitamin C for COPD.

And speaking of vitamin E, a posting yesterday estimated that 90% of Americans are deficient, and we learned long ago that not only vitamin C, but vitamin E and vitamin A are valuable improving lung health.
Owen R. Fonorow
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