Vitamin C Supplementation in the Critically Ill: A Systematic Review and Meta‐Analysis (not)

A discussion of Paul Marik's remarkable new therapy that cures a major killer in hospitals: Sepsis

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Vitamin C Supplementation in the Critically Ill: A Systematic Review and Meta‐Analysis (not)

Post Number:#1  Post by ofonorow » Fri Nov 23, 2018 11:53 am

Who doesn't love meta analysis?

“Statistics are like bikinis. What they reveal is suggestive, but what they conceal is vital.”

― Aaron Levenstein


https://onlinelibrary.wiley.com/doi/abs/10.1002/jpen.1471?af=R&

Only a meta analysis of garbage studies could find that Vitamin C doesn't help critically ill patients. (I wonder what this meta analysis was targeting?)

Eleven randomized trials were included. When 9 RCTs (n = 1322) reporting mortality were pooled, vitamin C was not associated with reduced risk of mortality (risk ratio [RR] 0.72, 95% confidence interval [CI]: 0.43–1.20, P = .21). No effect was found on infections, ICU or hospital LOS, or duration of MV. In multiple subgroup comparison, no statistically significant subgroup effects were observed

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Current evidence does not support supplementing critically ill patients with vitamin C.
Owen R. Fonorow
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