The "Lost" Science of Fasting - My experience

Focus on Hong Kong Dr. Leung's vitamin B5 discovery that megadoses of pantothenic acid maintain metabolism of a calorie deficit, leading to sustained weight loss without hunger, weakness or ketosis

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ofonorow
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Re: The "Lost" Science of Fasting - My experience

Post Number:#16  Post by ofonorow » Thu Dec 27, 2018 8:52 am

Revisiting
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950986/
w/r to the postulate that increase CoA - leads to higher metabolism (e.g. use of ATP).

It seems that much of this article concerns the study of B5 synthesis by the lowest organisms (who must make it, since they generally cannot "eat" it). Ergo, if the cell has to make pantothenate (B5) that requires the expenditure of energy, i.e., uses ATP.


Pantoate formation begins with the transfer of a methyl group to α-ketoisovalerate by ketopantoate hydroxymethyltransferase (the panB gene product) followed by reduction by ketopantoate reductase (the panE gene product). Pantothenate is then formed by the ATP-dependent condensation of β-alanine and pantoate by pantothenate synthetase (the panC gene product). Pantothenate is then either used for CoA biosynthesis or exported from the cell.


And it is interesting that virtually all microorganisms will absorb the vitamin (if available) leading to antibiotics based on this "universal absorption.

But I didn't find what I wanted regarding coenzyme A's contribution to cell or tissue or entire-body metabolism.
Owen R. Fonorow
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American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year

Johnwen
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Re: The "Lost" Science of Fasting - My experience

Post Number:#17  Post by Johnwen » Thu Dec 27, 2018 6:15 pm

Owen asked;
But I didn't find what I wanted regarding coenzyme A's contribution to cell or tissue or entire-body metabolism.


Enough Christmas I’m back!
The following is rat models but the science is the same.

Ok! first let’s look at what metabolic rate is and how it happens!
https://www.khanacademy.org/science/bio ... bolic-rate

Here’s a general overview of cellular action NoRats!
https://opentextbc.ca/anatomyandphysiol ... reactions/

Now we’ll move into Co-A etc. and see what it does!
https://res.mdpi.com/molecules/molecule ... tachment=1
Hope this link works! It's a PDF FIle 13pages!
To steal ideas from one person is plagiarism. To steal from many is
research!

ofonorow
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Re: The "Lost" Science of Fasting - My experience

Post Number:#18  Post by ofonorow » Mon Dec 31, 2018 6:40 am

Oh good - more home work.. Thx! Hope you had a nice Christmas.
Owen R. Fonorow
HeartCURE.Info
American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year


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