Keto's Fatal Flaw

Focus on Hong Kong Dr. Leung's vitamin B5 discovery that megadoses of pantothenic acid maintain metabolism of a calorie deficit, leading to sustained weight loss without hunger, weakness or ketosis

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Keto's Fatal Flaw

Post Number:#1  Post by ofonorow » Sun Dec 29, 2019 4:55 am

Thanks to Dr. Ken Berry's succinct discussion of Keto, in the context of the new Medical Medium knowledge, we can now say with some authority that the fatal flaw in the keto theory is categorizing carbs as "empty" calories.

Glucose is not an "empty" and addictive "calorie." It is a primary nutrient, like water, air and salt. Once understood, then everything starts to make sense. Yes, depriving the body of "sugar" can lead to rapid weight loss, but starving the body of glucose cannot be a long-term healthy life-style (unless you are an Intuit Eskimo, and even they have lost the gene for ketosis and no longer go into ketosis. [masterjohn])



Friend of Foundation wrote:If we are changing to the idea that fructose is bad and all or MM protocols involve lots of fruit (fructose) then do you think you should delete that so as not to confuse people?

Should I stop fruit?


Your fructose question is good. Keep eating fruit.

I think we know the answer about fructose being both good and bad thanks to Linus Pauling's book HOW TO LIVE LONGER AND FEEL BETTER, and his reference to Yudkin's book Sweet but Deadly. We all need to make some fat. That's how we survived through winters and during ice ages.

Fructose is a Fat On switch. Thanks to this documentary, which cites the book The Fat Switch (on our reading list)
https://youtu.be/-ygExIZm7Wo?t=415
around minute 6, we know the mechanism that causes the liver to manufacturer human fat. (Incidentally, uric acid prompts the liver to make fat.)

Eating fruits, we create and store fat in the summer that we burn during the winter. The key is that that eating fruits provides about 10 grams of fructose daily.

Enter the real bad guy: table sugar, sucrose - 1/2 glucose and 1/2 fructose. The Yudkin book Pauling cited informs us that at that time, people were eating 100 grams per day of sugar, of sucrose. This means they were eating 50 grams of glucose, but instead of 10 grams of Fructose, people in modern societies can eat something like 50 grams of fructose, or four times more than they would get simply eating fruit. Today, "sugar" is in everything, and lucky we even have "high fructose corn syrups"

Fructose in fruits is necessary so we don't waste away. Don't worry about eating fruits.

There are two known metabolic pathways to uric acid, as shown in the above Low Salt, More Fat documentary.

#1. Fructose (makes sense, we store fats when fruits are available) and

#2 LOW SODIUM also turns on the same (uric acid) switch.

Now we know how to keep the liver from producing fat. And thanks to Anthony, we know that the liver is where fat is made. (Didn't sound right when I first read MM. Also, we eat fat, but that is a different story.)

All coming together into a clear picture or unifying theory.

We know, glucose is like "air and water and salt" to the liver and brain (Thank you Anthony). Everyone on Keto believes that "carbs" are empty calories and that we crave sugar from addiction, like we crave alcohol or cocaine.

Once we understand that if we deprive our body of glucose - it will adjust to spare glucose for the brain/liver - by making other parts of the body insulin resistant. If muscles become insulin resistant, glucose won't be able to get into muscles, for example, so the body quickly becomes "fat adapted" and burns fat instead of glucose. This is good "insulin resistance" and a few aware N.D.s realize this condition is not necessarily bad. But they don't know why. Now readers here do. The brain and liver cannot burn fat, which is why glucose is not an "empty calorie."

And this is ultimately why keto, by restricting sugar (carbs), can lead to rapid fat loss. The body knows its in trouble from a lack of glucose.

Ergo glucose intake can be a regulator on how fast people lose weight. Eating less glucose is like pushing on the "fat burning" gas pedal.

However, you can reduce ordinary table sugars, and only take glucose, not make fat, and still burn fat, just not as fast. In fact, you can burn both glucose and fat at the same time, in different parts of the body.
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Re: Keto's Fatal Flaw

Post Number:#2  Post by ofonorow » Sat Jan 04, 2020 12:27 pm

https://www.dailymail.co.uk/health/article-4779346/Fructose-free-diet-cut-risk-obesity-days.html
Metabolism SPEEDS UP just 8 days after ditching fructose, study claims
Fructose is found in 75 percent of packaged food and drinks
It is converted into fat instead of digesting which adds extra weight to the body
Removing fructose from you diet helps lessen hunger and sugar cravings
One way to ditch fructose is by avoiding flavored yogurt and mixed drinks



Professor Jean-Marc Schwarz and colleagues from Touro University in California said removing fructose from the menu can combat obesity, fatty liver disease and diabetes without the need for medications.

It may be linked to liver conversion of sugar to fat, a process known as DNL (de novo lipogenesis), they said.

Compared to glucose, which metabolizes 20 percent in the liver and 80 percent throughout the rest of the body, fructose is 90 percent metabolized in the liver.

Fructose also converts to fat up to 18.9 times faster than glucose.
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Re: Keto's Fatal Flaw

Post Number:#3  Post by ofonorow » Sun Jan 19, 2020 11:13 am

Keto diet isn’t the answer for weight loss, experts say. Here’s what is
https://www.usatoday.com/story/news/hea ... 454401002/
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Re: Keto's Fatal Flaw

Post Number:#4  Post by ofonorow » Thu Feb 06, 2020 8:34 am

Having now read Dr. Richard J. Johnson's wonderful book THE FAT SWITCH, and understanding that a particular sugar, Fructose, is the main fat switch, how in the world do we turn it off?

Fructose is half of cane sugar (table sugar) and if you check food labels, sugar is added to almost everything, meaning fructose is added to almost everything. I thought I noticed that a few Gatorades are sweetened only with dextrose, but I may have missed that they have dextrose AND sugar. (Dextrose is D-glucose - glucose).

Johnson's lab has documented that if fructose is restricted, that the body can make some fructose out of glucose.

His lab has also documented that sugar in water, especially fructose in water (e.g., think regular coke and pepsi with High Fructose Corn Syrup) is many times better at turning on fat production than fructose in solid fruits.

We can understand that a ketogenic (low carb) diet can lead to rapid weight loss because the fructose/uric acid fat switch is turned off. Few or no carbs, little sugar. The flaw, as per the title of this thread, is that both the brain and liver require the sugar glucose, almost as much as they require oxygen or water. Both the brain and liver store glucose in the form of glycogen, which is used during sleep to keep blood sugar (glucose) levels constant. As glycogen stores are depleted, people start to feel unwell. For this reason, many low-carb diets now recommend adding fruits, which is an excellent idea.

The conundrum is that we need adequate glucose for our livers and brains, but we should learn to avoid ordinary table sugar like the plague.

One answer that pops out of this analysis is Jason Fung's fasting, or even intermittent fasting. Fung believes that people lose weight because insulin levels are reduced when no food is eaten. Johnson would argue that people lose weight during fasting because the Fat Switch is turned off by the lack of fructose.

The Anthony William, the medical medium, recommends restricting fat in the diet 20-30% of calories (and also says we eat too much protein.) His advice is to consume mainly solid fruits and vegetables as the staple of a proper diet. William also recommends grazing, eating a fruit and vegetable every 2 hours, to rest the adrenals, (which would otherwise have to produce a steroid to signal the liver to release glyogen/glucose - to keep sugar levels constant.)

There are Fructose-restricted diets, but my guess is that they mistakenly restrict fruit. A future answer may be healthy foods baked with dextrose (glucose) rather than ordinary sugar. Until then, either a keto-starter, to become fat adapted, or some variant of Fung's fasting is probably required to lose weight, and to keep it off.

If others have ideas how to restrict fructose, while not depriving the brain or liver of glucose, I am all ears!

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Re: Keto's Fatal Flaw

Post Number:#5  Post by Gary Springer » Thu Feb 06, 2020 12:08 pm

My understanding of some of the physiology necessary for understanding the subject at hand is as follows:

Glycogen stores throughout the body are completely depleted by day 3 of a water only fast.

When glycogen stores are depleted, by a process of gluconeogenesis the body produces glucose from muscle protein to maintain circulating blood glucose levels. That is why people can live 40 to 60 days on water only and maintain circulating glucose levels.

When glycogen stores are depleted, the brain functions primarily on energy from ketones, not glucose. And, when your body arrives in this energy status, when it’s main energy source is consistantly ketones for several days, the result is an amazing clarity and increased insight. It is the complete absence of “mind fog”. The brain is in no way fatigued, but instead in an energized state.

Right? Wrong? Thank you!

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Re: Keto's Fatal Flaw

Post Number:#6  Post by jimmylesante » Thu Feb 06, 2020 9:54 pm

In the USA Today article as soon as i see anyone , in this case Malik saying limit saturated fat----i realise they havent learnt anything since their university days 50 years ago.
Doctors also immediately think ketosis as bad as they have been trained to treat disease and not health.

A ketogenic diet provides plenty of sugar or ketones via fat or protein breakdown. The hrt comes in the first 3-4 days when your body transitions from sugar to ketones. Beyond that you run on ketones which is jet fuel compared to glucose.
The secret to weight loss and ketogenic diet is to measure your fat/muscle mass loss to ensure you are losing fat and gaining lean muscle mass.

Granted many people overdo the proeins and wonder why they are 1)no longer in ketosis(protein broken down into sugars) 2)no longer losing weight.

In reality we are born into ketosis and spend at least 6months or up to 2yrs drinking breast milk alone which is protein fats and lactose----perhaps the best quality ketogenic drink out there :)

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Re: Keto's Fatal Flaw

Post Number:#7  Post by ofonorow » Fri Feb 07, 2020 9:20 am

When glycogen stores are depleted, the brain functions primarily on energy from ketones, not glucose. And, when your body arrives in this energy status, when it’s main energy source is consistently ketones for several days, the result is an amazing clarity and increased insight. It is the complete absence of “mind fog”. The brain is in no way fatigued, but instead in an energized state.


I've always wondered about the science behind the idea that the brain can operate on ketone bodies. The "study" that turned the tied apparently was of a person in ketoacidosis who should have been brain dead. The assumption was that they lived by utilizing ketones, with very little support. I don't know of any experiments that prove a brain can function (can derive its energy) from ketone bodies.

And we learn from Masterjohn that the Intuit Eskimos, who should exist in constant ketosis, have actually evolved to lose the gene that causes ketosis! See: https://youtu.be/Viqm9Ona4SI

Granted, I've only read (most) of the Medical Medium series, by Anthony William, once, but my memory is that there is no mention of ketosis or ketone bodies in these books. And if fact, Anthony reveals the startling information that our brains, rather than made "mostly" of fat/lipids, is mostly carbohydrate. And that the brain has a variant form of glycogen storing glucose.

Then we add Dr. Leung's discovery (and theory) that ketosis, (which he states is an inefficient "fat burning" mechanism), occurs because of a deficiency in CoEnzyme A. That with sufficient coA, he was able to demonstrate that 100 people on a year long (1000 calorie) diet, did not enter ketosis, so long a they were given 10 g of vitamin B5 (panothenic acid) which is a direct CoA Precursor. His theory is in this paper: http://orthomolecular.org/library/jom/1997/pdf/1997-v12n02-p099.pdf

The absence of mind fog is interesting, and apparently a real outcome from fasting. In Jason Fung's intermittent fasting book, he mentions that physicians he works with, who do not necessarily believe in fasting, will fast to improve their mental clarity, i.e., for the effect fasting has on lifting mind fog. The medical medium may help us understand better mental acuity as more oxygen in the blood. According to Anthony William, fat in the blood stream reduces the oxygen level of the blood. We are told that oxygen in the blood is the main indicator of fat and this is how the liver determines how much bile to produce. Fasting by eliminating all foods, including fats, would thus improve blood oxygen levels.

The assumption that the brain has exceptional clarity "because of ketones" is one theory, but not one I think we can find scientific support for. I am willing to keep an open mind.
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Re: Keto's Fatal Flaw

Post Number:#8  Post by jimmylesante » Sat Feb 08, 2020 5:33 pm


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Re: Keto's Fatal Flaw

Post Number:#9  Post by ofonorow » Sun Feb 09, 2020 10:56 am

The discussion of the brain utilization of ketones in the above references relies on reference 20

Brain Metabolism during Fasting
https://www.jci.org/articles/view/105650

Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that β-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.


Although the fat depot may be massive and glycerol from neural fat can be converted to glucose, net gluconeogenesis from fatty acid carbon has not been demonstrated by mammalian systems. If the central nervous system does maintain an absolute requirement for glucose during starvation, this substrate must be derived from the limited carbohydrate stores...


What we learn from the 'advanced science' source that is the medical medium's, there is a large glucose storage in the brain, on the order of the liver, with a special from of glycogen. In fact, there is enough carbohydrate in the brain to make the brain mostly carbohydrate, rather than mostly lipid.

Three obese patients fasted for over a month, yet, there was glucose measured in the blood (page: 1591 using nmol/l measurements I am not used to.) The argument is that the levels of glucose measured are much lower than would normally be required to power the brain, ergo, the ketones measured must be powering the brain, as they are thought to do powering the rest of the body.

My first question to these authors, why have the Eskimos evolved to not go into ketosis on a high-fat (low carb) diet, and how do their brains get powered if not by ketones?

I would call this a nice try, to explain how the mammalian brain may function during starvation, and I will keep reading the main study to see what animal studies have been done. I did notice this gem

One should note, however, that ketones are incapable of maintaining or restoring normal cerebral function in the complete absence of glucose.


As an aside, the 3 patients in this "study" reminds me of the three patients in the Harvard Testosterone Study that prevents doctors from giving prostate cancer patients testosterone!
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Re: Keto's Fatal Flaw

Post Number:#10  Post by Gary Springer » Mon Feb 10, 2020 1:38 am

There is a substantial body of scientific evidence that shows the brain oxidizes ketones for energy when in a fasted state, and an overwhelming body of scientific evidence that the brain is comprised of mostly lipid, with a tiny amount of glycogen that is NOT a substantial source of glucose for most brain function after liver glycogen stores are depleted and the liver begins producing ketones.

As you know, main stream medicine constantly refutes the effectiveness of large doses of vitamin C as a cure and prevention of disease despite many hundreds, if not thousands, of scientific studies that support the fact that they do. The reason they design intentionally flawed studies to demonstrate the ineffectiveness of vitamin C is to sell the alternative; patented poisons that sometimes ameliorate symptoms but which are not designed to cure because with each cure is a loss of cash flow. If a research scientist writes otherwise, his career as a research scientist will be either short lived or must be funded by the tiny pool of money from non-traditional sources, and the latter rarely occurs.

Similarly. It is taught as scientific fact that glucose is the primary source of energy for the body, especially for the brain. However, there are hundreds if not thousands of scientific studies that demonstrate the many curative and health advantages of frequently entering ketosis and for fasting, and the science of ketones, their role in brain function, their antioxidant character, that they oxidize more clean without producing harmful oxygen species in the brain, their general effectiveness in improving health of the nervous system, increasing longevity and providing benefit to epilipsy and many other neurological disorders.
However, anyone who consistantly uses glucose as the primary fuel for the body will indeed have a short life. Only the body that frequently alternates between using glucose and lipids as a source of energy will be able to prevent weight increase to many hundreds of pounds.

If you think the increase of awareness and use of vitamin C would cut into big pharm profits, what do you think understanding and belief by the general population that fasting, intermittant fasting and low carb diets are healthful and often curative, what would that do to the profit of the food and drug industries? Imagine if it were common knowledge that most people would benefit by delaying the timing of the first meal of the day until 12:00! But, despite the rates of obesity in the nation, they continually
hammer home the belief that breakfast is the most important meal of the day and that the body needs that food to jump start calorie burning, thus making eating breakfast an important part of maintaining a healthy weight.

The science is there. But the understanding, like the understanding of the value of vitamin C, is lost in a continual barage of misinformation.

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Re: Keto's Fatal Flaw

Post Number:#11  Post by ofonorow » Tue Feb 11, 2020 7:43 am

There is a lot to digest, but focusing on

Similarly. It is taught as scientific fact that glucose is the primary source of energy for the body, especially for the brain. However, there are hundreds if not thousands of scientific studies that demonstrate the many curative and health advantages of frequently entering ketosis and for fasting, and the science of ketones, their role in brain function, their antioxidant character, that they oxidize more clean without producing harmful oxygen species in the brain, their general effectiveness in improving health of the nervous system, increasing longevity and providing benefit to epilipsy and many other neurological disorders.
However, anyone who consistantly uses glucose as the primary fuel for the body will indeed have a short life. Only the body that frequently alternates between using glucose and lipids as a source of energy will be able to prevent weight increase to many hundreds of pounds.


What I learned from Dr. Leung is that ketones only form when CoA is in short supply, and that their presence indicates that the body is inefficiently burning lipids. His experiment showed that 100 people on a year-long 1000 calorie diet did not go into ketosis - so long as sufficient CoA precursor was provided (i.e., 10 g vitamin B5).

Furthermore, Masterjohn research illustrates that fact that the Intuit eskimos have evolved and lost the ability to go into ketosis.

Thirdly, we know that the body tightly regulates blood glucose to a narrow range around 90 mg/dl, and that the pancreas and liver keeps us alive during sleep by maintaining this level of glucose in the blood.

Fourth, the Medical medium tells us something different, that the primary fuel for both the brain and liver is glucose, much like water, air, etc. Glucose is a primary nutrient, and that the brain is "mostly" carbohydrate :-) The studies showing ketosis supports the brain merely show that ketones are present, not that the brain utilizes them for energy. (We could probably add an argument about ketoacidosis...)

From the Medical Medium, it becomes apparently that the body becomes "insulin resistant" to spare glucose for the brain and liver. The muscles and other parts of the body become fat adapted, and burn lipids for energy.
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Re: Keto's Fatal Flaw

Post Number:#12  Post by jimmylesante » Tue Feb 11, 2020 10:44 am

I agree that glucose is needed for the brain-or some parts of the brain . But my question is where does the glucose come from? Is it necessary to ingest the glucose or can it be broken down from protein or fat(those innuits) and utilised as and when needed.
Diabetes is a 3 stage disease isn't it, the 3rd stage being the brain .

Ketosis provides the body with enough building blocks that the body can choose how much glucose to make in order to work optimally.
For me personally if i had more than 50g(2x big carrots) of carbohydrate i'd be knocked out of ketosis.
Interestingky and similarly if i had too much eggs and jerky or fat i'd be knocked out of ketosis-because the body would have excess to break down into glucose. I'm guessing how the innuits are not in ketosis because they are eating too much protein/fats.

With regards using ketones as primary fuel for the brain in the absence of glucose why not? It certainly focuses the brain and provides extraordinary amounts of energy-designed so the cave man could chase down their next prey and gorge.
As such i don't think ketosis is a long term thing- and should intermittently be broken up after weeks or months with some carbohydrates such as fruit/vegetable/nuts.
Some of the best triathletes utilise ketosis and glycolysis during their endurance races.

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Re: Keto's Fatal Flaw

Post Number:#13  Post by popnowlin » Mon Feb 17, 2020 7:50 am

I'm not a huge fan of "conventional" science. It's been so corrupted by money and politics that it's almost unrecognizable these days. However, if the alternative is information from a spirit guide science wins every time.
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Re: Keto's Fatal Flaw

Post Number:#14  Post by johnjackson » Mon Feb 17, 2020 8:15 am

can someone just tell me what ketos flaw is?
is it lack of glucose/fructose?
I thought it was veggies, too much keto foods(high fat/protein) gets you backed up
/www.medicalnewstoday.com/releases/12154.php


medcraveonline.com/JCCR/JCCR-09-00341.php

//riordanclinic.org/2014/02/high-dose-intravenous-vitamin-c-as-a-successful-treatment-of-viral-infections/

lpa
http://www.drkaslow.com/html/lipoprotein_a.html

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Re: Keto's Fatal Flaw

Post Number:#15  Post by ofonorow » Mon Mar 23, 2020 3:10 pm

Flaw is considering glucose as "empty" calories, rather than vital fuel, especially brain and liver fuel it really is. I think i now understand that no nutrients are absorbed without glucose present.


Minor flaws. We need little protein and fat should be plant based and restricted to 20% of calories.

Now that I know that fructose turns on the production of fat in the liver, my weight is 200 lbs, down from over 250 lbs a couple if years ago when i began the vitamin B5 journey.
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