Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage
Posted: Mon Nov 05, 2018 11:19 am
https://www.nature.com/articles/s41598-018-34530-4
This newly published study adds to the already enormous body of scientific literature demonstrating the beneficial effects of topical vitamin C. Of particular interest here:
This newly published study adds to the already enormous body of scientific literature demonstrating the beneficial effects of topical vitamin C. Of particular interest here:
- Demonstration of significant conversion of AA to dehydroascorbic acid (DHAA) in skin;
- Demonstration of TNF-alpha inhibition by AA. Combined with the previously demonstrated NFkB inhibition by DHAA, it indicates vitamin C blocks two different steps in the TNF alpha/NFkB inflammatory cascade. This synergism possibly explains the excellent anti-inflammatory effects of topical vitamin C in sun exposure.