Post
by gofanu » Tue Feb 24, 2015 2:41 am
Sorry to hear Prof Ely is gone, we are so much the poorer. A truly great mind of science.
I do not have any GAA paper as such; all I find is an abstract available:
Protein Glycation: Ascorbate Antagonism.
Bulletin Amer Physical Society, 33(3):296, 1988 (abst).
C9 1 Protein Glycation: Ascorbate Antagonism. J.T.A. Ely, U Washington, G.A. Warner, Northwest Oncology Clinic, D.H. Read & G.A. Santisteban, Seattle U -- Loss of elasticity and solubility, and degradation of other physical properties of proteins and nucleic acids have been reported to result from non enzymatic glycation as well as the associated cross-linking. (1). We present evidence that glycation of hemoglobin is significantly antagonized in animals and humans by pharmacologic daily supplementation of ascorbate at 50mg/kg and above. We explain that : (1) the antagonism is expected to be even stronger for other proteins; and (2) continuous elevation of ascorbate may be necessary for effective antagonism. We discuss the possible relevance to aging , birth defects, cancer, cataracts and other lesions.
*Supported by Northwest Oncology Foundation.
1. A. Cerami, H. Vlassara & M. Brownlee, Scientific American 256(5), 82 (1987)
But, the idea and applications are explained in many of his papers, with varying details. I have copies but most of the links are to his old U-Wa site. I suppose I could simply send you my whole folder (15 papers), if you give me an address.
re diabetes/VC
Unrecognized Pandemic "Subclinical"Diabetes of the Affluent Nations:
Causes, Cost and Prevention
John T. A. Ely, Ph.D.
Journal of Orthomolecular Medicine, 1996; 11(2): 95-99.
FRM