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There are other points of contention, but I have noticed that when Fife conflicts with the MM, there are no references??
Dominant sympathetic types: Typ ‘A’ personalities, disciplined; mostly solid cancers; do good on much plant based foods: fruits, vegies, seeds, grains, nuts, plant based oils: hemp, flax; Vitamin B1, B2, B3, 8:1 ratio magnesium to calcium, high vitamin C & D; but not on much meat protein, no b12, no choline, no B5, no zinc, no selenium, no fish oil. Yes to beta Carotene, chromium, folic acid, riboflavin, thiamin,& niacin
Parasympathetic: types are rather creative with unconventional ‘formal’ education; mostly blood-based cancers; do good on lots of meat and a ketogenic diet, saturated fats, fats from fish oils, Calcium 10-15 ratio to magnesium (high magnesium causes depression), Vitamin B12, B5, Choline; not as good on grains or seed. Need zinc & selenium, not good with other large Vitamin B doses.
Mixed or balanced types: suffer rather from allergies and fatigue.
### Scientific Literature on Coconut Oil and Insulin Sensitivity
#### Coconut Oil and Insulin Resistance
A systematic review and meta-analysis of 11 interventional studies revealed that the consumption of coconut oil seems to increase insulin resistance. The certainty of this evidence ranges from very low to moderate, indicating that while some studies suggest this outcome, the overall confidence in these findings is not strong[3].
#### Animal Studies on Coconut Oil
Animal studies have provided mixed results. One study demonstrated that a diet rich in coconut oil protected against insulin resistance in muscle and fat in mice. This study suggested that medium-chain fatty acids (MCFAs), such as those found in coconut oil, are metabolized differently compared to long-chain fatty acids, potentially leading to better insulin action and less fat storage in muscle[1]. However, another study found that coconut oil disrupted the ability of mice to use leptin and insulin properly, contributing to insulin resistance and obesity[5].
#### Human Studies and MCTs
Human studies on the effects of coconut oil on insulin sensitivity are limited and often yield conflicting results. For example, one small study in nine healthy men showed that consuming coconut oil for eight weeks enhanced insulin sensitivity, supporting healthy blood sugar levels[2]. However, it is important to note that coconut oil is not synonymous with pure MCT oil used in some research. MCT oil is composed almost entirely of C8 and C10 fatty acids, whereas coconut oil contains a significant amount of C12 fatty acids, which are metabolized more like long-chain triglycerides.
A case report highlighted a diabetic patient who experienced recurrent hypoglycemia and decreased insulin requirements after adding coconut oil to their diet. The metabolic and anti-inflammatory properties of coconut oil were hypothesized to contribute to these effects[4].
### Conclusion
The scientific literature on coconut oil and insulin sensitivity presents a complex picture:
- **Systematic Reviews and Meta-Analyses**: Suggest an increase in insulin resistance with coconut oil consumption[3].
- **Animal Studies**: Provide mixed results, with some indicating protective effects against insulin resistance[1] and others showing disruption in insulin and leptin signaling[5].
- **Human Studies**: Limited and conflicting, with some small studies suggesting enhanced insulin sensitivity[2][4].
Overall, while some evidence points to potential benefits of MCTs in improving insulin sensitivity, the specific effects of coconut oil are less clear and may differ due to its unique composition. More rigorous human studies are needed to draw definitive
conclusions.
### References
1. [Garvan Institute of Medical Research - How coconut oil could help reduce the symptoms of Type 2 diabetes](https://www.garvan.org.au/news-resource ... 2-diabetes)
2. [Healthline - Coconut Oil and Diabetes: Know the Facts](https://www.healthline.com/health/cocon ... d-diabetes)
3. [ScienceDirect - Effects of consumption of coconut oil or coconut on glycemic control and insulin sensitivity: A systematic review and meta-analysis of interventional trials](https://www.sciencedirect.com/science/a ... 5321004543)
4. [NCBI - The Glucose-Lowering Effects of Coconut Oil: A Case Report](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781718/)
5. [Medical News Today - Coconut oil may alter metabolism and cause obesity, mouse study shows](https://www.medicalnewstoday.com/articl ... tudy-shows)
Ketone therapy in the form of the ketogenic diet has been used successfully for 90 years to treat epilepsy. Recent research has shown that ketone therapy can also be of benefit in treating Alzheimer’s, Parkinson’s, Huntington’s, MS, and a number of other neurological disorders. Neurodegenerative disorders involve a disruption of the brain’s ability to metabolize glucose and produce energy. Ketones have been the key to bypass this defect, maintain energy levels, and normalize brain function.
...high blood ketone levels have not been shown to be any more effective than much lower levels.
Ketone therapy, whether through a ketogenic diet or the administration of MCTs or ketone-producing medications, strives to provide the brain with the fuel it needs to achieve and maintain normal, healthy function. With this in mind, some investigators have assumed that the higher the blood ketone levels are, the better. Research is being done to develop drugs that can increase ketone levels 10 times higher than what is possible from eating coconut or MCT oils. While some level of ketosis is necessary in order to supply the brain with the energy it needs, high blood ketone levels have not been shown to be any more effective than much lower levels. The idea that “more is better” isn’t necessarily true when it comes to ketones. This is apparently the case with seizure control in epileptics. Measures of seizure protection and seizure incidence with ketones levels do not correlate.1
We always have measurable concentrations of ketones in our blood and urine regardless of our diet. The concentration of beta-hydroxybutyrate (BHB), the primary ketone, is typically around 0.1 mmol/l (millimoles per liter). During starvation or prolonged fasting, BHB levels increase to 2-7 mmol/l, which is also the same level achieved on the classic ketogenic diet. Therapeutic levels of ketosis that are effective in treating Alzheimer’s disease can be achieved with blood levels of BHB less than 0.5 mmol/l.2 This level can easily be achieved by consuming a 2 tablespoon dose of coconut oil. Blood levels of ketones at about this level have shown to be just as effective as those which are many times higher and typically associated with the ketogenic diet.3 High ketone levels are not necessary. You can think of it like filling the gas tank of your car. The tank can be filled to the top with fuel, but the engine can only burn a little at a time. The amount of gas in the tank has no effect on the rate at which the engine can burn the fuel. As long as enough gas is available to keep the engine continually running, it doesn’t matter how full the tank is. The same is true with ketones. Pumping the body with more ketones than it needs will have no additional benefit. Excess ketones are not stored, like fuel is in the gas tank, or like glucose (which is stored as glycogen or fat). Ketones have a short life span in the blood. If they are not used within a few minutes, they are flushed out of the body in the urine.
So a large influx of ketones into the bloodstream will end up being removed from the body and do absolutely no good. Even when blood ketones are high, the addition of carbohydrate into the diet can initiate seizures. It is apparent that blood glucose levels also have an influence on brain function. Ketone therapy alone is not the complete answer.
Controlling blood glucose levels is also vitally important. While excessive ketone levels are not necessary, therapeutic levels should be maintained constantly throughout the day and night.
Medications or supplements that boost ketone levels only last a few hours and need to be retaken often. During the day this is not a big problem, but at night it can be. At night, ketosis tapers off, and by morning, it is gone. Ketone therapy prevents the brain from dying during the day, but when ketones run out, the brain is starved and death and degeneration continue.
The two errors in my opinion are 1) crediting ketones with benefits, and 2) assuming that the coconut oil's benefit comes from ketosis. Coconut oil can have great benefits that have nothing to do with ketone bodies.Coconut oil is better than current ketone medications or MCT oil because it produces ketones over a much longer period of time, up to eight hours. Taken just before bedtime, coconut oil keeps ketone levels elevated through the night. ... Even a mild ketogenic diet, when combined with the coconut oil, can maintain ketosis at a therapeutic level. Coconut oil is consumed only at mealtime, so it doesn’t interfere with sleep. The brain is never denied the energy it needs. Healing continues night and day.
Fife, Bruce. Stop Alzheimer's Now! Piccadilly Books, Ltd. Kindle Edition.
My concern or question is whether the high fat diet is really good for Alzheimer's/memory, since I am quite convinced that Ketones cannot be used for energy, and are in fact waste, a by-product of fat metabolism. When you burn fat without sufficient vitamin B5 you go into ketosis. I've gone through Fife's references looking for the answer, but so far to no avail.I have been using Dr. Fife's dietary plan for about a year now. I also have read all his books on coconut oil. I apply the Coconut Ketogenic Diet by Dr, Fife. My numbers have been slightly high overall cholesterol numbers (200). I use carbs at 50g - 80g. I try for a fats of 40% - 50%.
Because saturated fats are not susceptible to lipid peroxidation, they have not been found to be involved in these mechanisms.
There is a conundrum however, lauric acid is supposedly highly "combustible" in that it oxidizes quickly and coconut oil is the primary source?!?!Which fats are most likely to oxidize?
Unsaturated fats are more prone to rancidity compared to saturated fats due to their chemical structure and susceptibility to oxidation.
Double bonds: Unsaturated fats contain one or more double bonds in their fatty acid chains.
Saturated lipids are much more stable to oxidation than unsaturated lipids, which makes them desirable in foods very susceptible to oxidation such as frying oils (2, 8, 36). Double bonds increase the susceptibility of FAs to oxidation, with an increasing number of double bonds increasing oxidative susceptibility.May 7, 2015
Coconut oil is made up of about 90% saturated fats and 9% unsaturated fats. However, the saturated fats in it differ from saturated fats in animal fats. Over 50% of the fats in coconut oil are medium chain fatty acids, such as lauric acid (12:0). Coconut oil is the highest natural source of lauric acid.
Conclusions: In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.
What is he source of this statement?Conclusions: In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.
What is he source of this statement?Conclusions: In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.
Conclusions:
In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.
Herein lies the uniqueness of coconut oil. Coconut oil is made up of about 90% saturated fats and 9% unsaturated fats. However, the saturated fats in it differ from saturated fats in animal fats. Over 50% of the fats in coconut oil are medium chain fatty acids, such as lauric acid (12:0). Coconut oil is the highest natural source of lauric acid. Lauric acid and its derivative monolaurin constitute around 50% of coconut fat-derived lipid.
I could be wrong, but if you reread Fife, in his opinion, this is because of ketosis. His idea is to keep ketosis going 24/7. Coconut oil does promote ketosis. He believes that ketones (lipid metabolisim "waste" products) provide energy for the brain.The brain uses fat as a fuel source. As per Dr, Fife if the brain were to run out of fat, it would die. The only problem is I overlooked the one thing that is important is timing. The use of coconut oil is a timing event. You should use the coconut oil throughout the day. Coconut oil is good for about three- or four-hours' worth of energy.
What I think I know is that the brain uses glucose as its only fuel source and if the brain were to run out of glucose, we'd die. Fife agrees, but has bought into the idea that ketones can also power the brain.Normally the brain uses glucose to satisfy its energy needs. If glucose is not available, one of the only other sources of fuel it can use is ketone bodies or ketones. Other organs and tissues in the body can utilize fat for energy, but not the brain—it must have either glucose or ketones
Fife, Bruce. Stop Alzheimer's Now! (pp. 161-162). Piccadilly Books, Ltd. Kindle Edition.
With Pauling and the medical medium in mind, you went wrong by not taking optimal vitamin C (which is at least 40 mg/kg daily) and eating a high fat diet.This is probably where I went wrong! I had a stroke last month (July) and I was put on blood thinners. My blood pressure mysteriously went from 124/90 to 187/101. But I can only think it's because of the many pills that I take! If you take coconut oil your cholesterol settles in around 200. Which by the way, doctors want you on a statin (which I refuse). It is said that people with a cholesterol reading of 200 live the longest.
Mucuna Pruniens is a "natural" form of L-Dopa, but Big Pharma says it doesn't reach the brain as well as the levedopa/carbidopa drug. In any case, you risk keeping your own production of dopamine diminished by taking either. The information in this regard from Coleman seems pertinent. If I can get my wife off external forms of L-Dopa, I'd be happy.I am taking three grams of Mucuna Pruniens. It has settled my shakes quite a bit, but I can't say any further if it's because I'm not working out. I take too many pills and sometimes think it's maddening! When I workout (aerobically), it causes my heart rate to increase and my shakes to increase.
I don't know where you got your Lauric Acid info but I think it's worth looking into. Lauric Acid is the whole thing that oil pulling is all about! The lauric Acid is what is killing the bacteria in your mouth! The Lauric Acid in coconut oil is about 53%'
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