Is Parkinson's an anandamide deficiency?

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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Thu Aug 01, 2024 2:32 pm

I am enjoying Bruce Fife's STOP ALZHEIMER'S NOW, and there is a lot of what I hope is valid information.

There is a lot of data, and I happen to agree with Fife that there is nothing dangerous about so-called "saturated fat." Fife considers SF to be a "health food" (unlike polyunsaturated fats which oxidize and can go rancid. He rightly points out that the explosions in heart disease, cancer and diabetes followed shortly after the introduction polyunsaturated (and trans fats) into our diets.)

Fife cites research that the neurological diseases are more prevalent in people on low-fat diets. He plants the suggestion that eating more fat is good for the aging brain.

And there are various other points where either Bruce Fife is correct, and the Medical Medium is wrong, or visa versa. If the Medical Medium is wrong, it would be the "black swan" the proves that William's Medical Medium information is fallible. For example,

#1 - Fat as the cause of insulin resistance.

Fife concludes that Medium Chain Triglycerides (MCT) in Coconut Oil ENHANCE insulin sensitivity. The Medical Medium as I understand it contends that fats are the currently unknown CAUSE of insulin resistance. Fife provides case studies where coconut oil is made to sound like the best diabetes drug out there, and he claims that coconut oil can regulate blood sugar and reduce insulin requirements. (I plan to run experiments to find out if this is true.)

If it is true, it may mean that Coconut Oil and Medium Chain Triglycerides, rather than block insulin, somehow enhance it?


#2 - Ketones can be used by the brain for energy.

In all Medical Medium books, ketones are not mentioned once. They say that the brain derives all its energy from glucose, with the exception that it can run for a short period on adrenaline. We learned from Hong Kong doctor Leong (back in our vitamin B5 days) that ketones are the product of incomplete combustion, i.e., that ketones are remnants of the body burning fat when vitamin B5 is deficient. And, that by adding vitamin B5, fat burning is made more efficient and ketones are not produced.

We learned that the Intuit Eskimoes have a genetic "enhancement" which prevents them from going into ketosis eating fat, etc.

And the memory miracles from taking Coconut oil are almost immediate, so it is unlikely these miracles rely on the body going into ketosis.

#3 - Ketogenic Diet for Epilepsy

The Medical Medium blames Epilepsy on toxic heavy metals, an usually a pair of concentrated toxic heavy metal deposits (They do list at least 10 other possible reasons) And the problem of seizures in general is blamed on the heat generated by these metals in the brain. Glucose cools the brain.

It is an interesting puzzle how such a high-fat diet prevents seizures, but beyond the scope of this course.

There are other points of contention, but I have noticed that when Fife conflicts with the MM, there are no references??
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Re: Is Parkinson's an anandamide deficiency?

Post by pamojja » Sat Aug 03, 2024 6:53 am

There are other points of contention, but I have noticed that when Fife conflicts with the MM, there are no references??

For me, the puzzle is easily solved be the experience of different metabolic types by the late Dr. Nickolas Gonzales.

Dominant sympathetic types: Typ ‘A’ personalities, disciplined; mostly solid cancers; do good on much plant based foods: fruits, vegies, seeds, grains, nuts, plant based oils: hemp, flax; Vitamin B1, B2, B3, 8:1 ratio magnesium to calcium, high vitamin C & D; but not on much meat protein, no b12, no choline, no B5, no zinc, no selenium, no fish oil. Yes to beta Carotene, chromium, folic acid, riboflavin, thiamin,& niacin

Parasympathetic: types are rather creative with unconventional ‘formal’ education; mostly blood-based cancers; do good on lots of meat and a ketogenic diet, saturated fats, fats from fish oils, Calcium 10-15 ratio to magnesium (high magnesium causes depression), Vitamin B12, B5, Choline; not as good on grains or seed. Need zinc & selenium, not good with other large Vitamin B doses.

Mixed or balanced types: suffer rather from allergies and fatigue.

Where experimentation in diet and supplementation do show the according results. I seem to be a mixed type and had to change from 30 years of a low fat vegetarian diet to high fat (mainly coconut oil), daily eggs, weekly fish, and occasional offal and meat (wild caught or organically grass fed).

For scientific references to verify AI is very good. Asked your question with scientific references complexity.ai:

### Scientific Literature on Coconut Oil and Insulin Sensitivity

#### Coconut Oil and Insulin Resistance

A systematic review and meta-analysis of 11 interventional studies revealed that the consumption of coconut oil seems to increase insulin resistance. The certainty of this evidence ranges from very low to moderate, indicating that while some studies suggest this outcome, the overall confidence in these findings is not strong[3].

#### Animal Studies on Coconut Oil

Animal studies have provided mixed results. One study demonstrated that a diet rich in coconut oil protected against insulin resistance in muscle and fat in mice. This study suggested that medium-chain fatty acids (MCFAs), such as those found in coconut oil, are metabolized differently compared to long-chain fatty acids, potentially leading to better insulin action and less fat storage in muscle[1]. However, another study found that coconut oil disrupted the ability of mice to use leptin and insulin properly, contributing to insulin resistance and obesity[5].

#### Human Studies and MCTs

Human studies on the effects of coconut oil on insulin sensitivity are limited and often yield conflicting results. For example, one small study in nine healthy men showed that consuming coconut oil for eight weeks enhanced insulin sensitivity, supporting healthy blood sugar levels[2]. However, it is important to note that coconut oil is not synonymous with pure MCT oil used in some research. MCT oil is composed almost entirely of C8 and C10 fatty acids, whereas coconut oil contains a significant amount of C12 fatty acids, which are metabolized more like long-chain triglycerides.

A case report highlighted a diabetic patient who experienced recurrent hypoglycemia and decreased insulin requirements after adding coconut oil to their diet. The metabolic and anti-inflammatory properties of coconut oil were hypothesized to contribute to these effects[4].

### Conclusion

The scientific literature on coconut oil and insulin sensitivity presents a complex picture:

- **Systematic Reviews and Meta-Analyses**: Suggest an increase in insulin resistance with coconut oil consumption[3].
- **Animal Studies**: Provide mixed results, with some indicating protective effects against insulin resistance[1] and others showing disruption in insulin and leptin signaling[5].
- **Human Studies**: Limited and conflicting, with some small studies suggesting enhanced insulin sensitivity[2][4].

Overall, while some evidence points to potential benefits of MCTs in improving insulin sensitivity, the specific effects of coconut oil are less clear and may differ due to its unique composition. More rigorous human studies are needed to draw definitive
conclusions.

### References

1. [Garvan Institute of Medical Research - How coconut oil could help reduce the symptoms of Type 2 diabetes](https://www.garvan.org.au/news-resource ... 2-diabetes)
2. [Healthline - Coconut Oil and Diabetes: Know the Facts](https://www.healthline.com/health/cocon ... d-diabetes)
3. [ScienceDirect - Effects of consumption of coconut oil or coconut on glycemic control and insulin sensitivity: A systematic review and meta-analysis of interventional trials](https://www.sciencedirect.com/science/a ... 5321004543)
4. [NCBI - The Glucose-Lowering Effects of Coconut Oil: A Case Report](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781718/)
5. [Medical News Today - Coconut oil may alter metabolism and cause obesity, mouse study shows](https://www.medicalnewstoday.com/articl ... tudy-shows)

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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Sun Aug 04, 2024 5:10 pm

Yes, the metabolic type (how fast food moves through the digestive tract) explains a great deal, i.e. why some people do better digesting meat, and other plants.

So far, MCT oil has made no difference in my measured blood sugar levels or insulin requirement. I may try coconut oil.

Fife's diet would no doubt improve the health of many who follow it, especially from the lack of refined and processed foods. However few would be able to follow it for long. Not only is it high fat, but fruits are to be avoided.

The main question, since the book is about Alzheimer's, is whether a low-fat or high-fat diet is better for neurological diseases.

Fife has made the assumption the ketones are fuel for the brain, and credits ketosis as the reason fats are beneficial.

Ketone therapy in the form of the ketogenic diet has been used successfully for 90 years to treat epilepsy. Recent research has shown that ketone therapy can also be of benefit in treating Alzheimer’s, Parkinson’s, Huntington’s, MS, and a number of other neurological disorders. Neurodegenerative disorders involve a disruption of the brain’s ability to metabolize glucose and produce energy. Ketones have been the key to bypass this defect, maintain energy levels, and normalize brain function.

Either Fife is wrong that ketones are the key to bypass "this defect," or the Medical Medium's source is wrong.
For example, Fife writes:

...high blood ketone levels have not been shown to be any more effective than much lower levels.


Ketone therapy, whether through a ketogenic diet or the administration of MCTs or ketone-producing medications, strives to provide the brain with the fuel it needs to achieve and maintain normal, healthy function. With this in mind, some investigators have assumed that the higher the blood ketone levels are, the better. Research is being done to develop drugs that can increase ketone levels 10 times higher than what is possible from eating coconut or MCT oils. While some level of ketosis is necessary in order to supply the brain with the energy it needs, high blood ketone levels have not been shown to be any more effective than much lower levels. The idea that “more is better” isn’t necessarily true when it comes to ketones. This is apparently the case with seizure control in epileptics. Measures of seizure protection and seizure incidence with ketones levels do not correlate.1

In summary, according to Fife blood levels don't matter, we always have some level of ketones. Pumping the body with more ketones than it needs will have no additional benefit. Excess ketones are not stored, like fuel is in the gas tank, or like glucose (which is stored as glycogen or fat). Ketones have a short life span in the blood. If they are not used within a few minutes, they are flushed out of the body in the urine.
We always have measurable concentrations of ketones in our blood and urine regardless of our diet. The concentration of beta-hydroxybutyrate (BHB), the primary ketone, is typically around 0.1 mmol/l (millimoles per liter). During starvation or prolonged fasting, BHB levels increase to 2-7 mmol/l, which is also the same level achieved on the classic ketogenic diet. Therapeutic levels of ketosis that are effective in treating Alzheimer’s disease can be achieved with blood levels of BHB less than 0.5 mmol/l.2 This level can easily be achieved by consuming a 2 tablespoon dose of coconut oil. Blood levels of ketones at about this level have shown to be just as effective as those which are many times higher and typically associated with the ketogenic diet.3 High ketone levels are not necessary. You can think of it like filling the gas tank of your car. The tank can be filled to the top with fuel, but the engine can only burn a little at a time. The amount of gas in the tank has no effect on the rate at which the engine can burn the fuel. As long as enough gas is available to keep the engine continually running, it doesn’t matter how full the tank is. The same is true with ketones. Pumping the body with more ketones than it needs will have no additional benefit. Excess ketones are not stored, like fuel is in the gas tank, or like glucose (which is stored as glycogen or fat). Ketones have a short life span in the blood. If they are not used within a few minutes, they are flushed out of the body in the urine.

Fife explains that a large influx of ketones into the bloodstream will end up being removed from the body and do absolutely no good.

Fife writes: "Ketone therapy alone is not the complete answer"
So a large influx of ketones into the bloodstream will end up being removed from the body and do absolutely no good. Even when blood ketones are high, the addition of carbohydrate into the diet can initiate seizures. It is apparent that blood glucose levels also have an influence on brain function. Ketone therapy alone is not the complete answer.
Controlling blood glucose levels is also vitally important. While excessive ketone levels are not necessary, therapeutic levels should be maintained constantly throughout the day and night.

This is where a reference about "therapeutic ketone levels" would be useful.
Medications or supplements that boost ketone levels only last a few hours and need to be retaken often. During the day this is not a big problem, but at night it can be. At night, ketosis tapers off, and by morning, it is gone. Ketone therapy prevents the brain from dying during the day, but when ketones run out, the brain is starved and death and degeneration continue.

A reference would be wonderful. The Medical Medium explains that like the liver, the brain has a form of glucose storage for periods when glucose in the blood (provided by the liver a night) goes low. Never a mention of the brain "starving to death" for lack of the waste produce we call ketone bodies.
Coconut oil is better than current ketone medications or MCT oil because it produces ketones over a much longer period of time, up to eight hours. Taken just before bedtime, coconut oil keeps ketone levels elevated through the night. ... Even a mild ketogenic diet, when combined with the coconut oil, can maintain ketosis at a therapeutic level. Coconut oil is consumed only at mealtime, so it doesn’t interfere with sleep. The brain is never denied the energy it needs. Healing continues night and day.

Fife, Bruce. Stop Alzheimer's Now! Piccadilly Books, Ltd. Kindle Edition.
The two errors in my opinion are 1) crediting ketones with benefits, and 2) assuming that the coconut oil's benefit comes from ketosis. Coconut oil can have great benefits that have nothing to do with ketone bodies.
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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Tue Aug 06, 2024 1:33 pm

Dick,

I need your opinion. You credit Fife's book with at least some of your recovery from Alzheimer's, do I have this right? I have little doubt that coconut oil does have a profound effect improving dementia/memory problems. As Fife writes, coconut oil/MCT oils work - regardless of the diet. Thank you for this knowledge. I also appreciate the knowledge that "amaloid" plaques of Alzheimer's are the body's immune response, not the cause, so that any therapy aimed at removing these plaques is misguided.

But I am having trouble with what Fife says is the most important part of his plan: A high-fat, low-carb diet. According to the Medical Medium, Fife's two lowest carb diets induce starvation (and even Fife admits that ketones are only formed during starvation).

Fife says his diet supplies all the nutrients needed (and it probably would if people adopted all the vegetables recommended) but the Medical Medium explains that without insulin, nutrients cannot be absorbed by the body. Glucose is required to stimulate the pancreas to release insulin.

There are more contradictions, but I am interested in what you think has improved your health and mind on the Fife program?

I have not finished the book, so maybe some case studies are forthcoming, but other than the Coconut Oil example, the book is so far devoid of examples of his program helping or reversing Alzheimer's patients. If the Medical Medium is correct, the Fife high fat diet should have the opposite effect over time.

The problem is a clash between fats (oils) and glucose. If the diet recommendations were adjusted such that the vegetable intake remained the same, the high-fat portion was eaten only as the last meal of the day, and the diet was adjusted to include fresh organic fruits during the day starting with breakfast, there would be no clash between lipids and glucose. Fife's diet 100 gram diet would then be healthy for body and mind.
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Re: Is Parkinson's an anandamide deficiency?

Post by dick » Wed Aug 14, 2024 4:29 pm

I have been using Dr. Fife's dietary plan for about a year now. I also have read all his books on coconut oil. I apply the Coconut Ketogenic Diet by Dr, Fife. My numbers have been slightly high overall cholesterol numbers (200). I use carbs at 50g - 80g. I try for a fats of 40% - 50%. My doctor recommends that I start a statin, but I decline. You should get carbs as they are important and my number is to avoid "Keto Flu."

I also must use my coconut oil to "Stop Vision Loss" by Dr. Fife. My right eye was almost blind. After four months of using two tablespoons a day. my right eye is as good as my left eye! I couldn't believe it!

Yes, I believe I feel better because I'm more aware of life. I woke up one morning and I was alert and more aware of my surroundings! I know this isn't very technical but it's all I have.

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Re: Is Parkinson's an anandamide deficiency?

Post by dick » Thu Aug 15, 2024 10:16 am

Now, back to John Coleman.

In his book, the chapter on supplements. He points out the individual supplements to take, but no mention of anything to boost dopamine or anandamide production! I guess those of us that follow the Pauling Protocol are doing alright.

Now in the chapter on feeling positive he says "Our attitude towards ourselves changes the way our body produces chemicals. If we are constantly self- critical, we maintain a level of fight/flight/freeze response that suppresses our immune function and production of dopamine (and serotonin and anandamide). If we grant ourselves unconditional love, and our innate beauty, we enhance immune function and the production of dopamine, serotonin and anandamide."

Therefor, I think we should be looking for the things that are responsible for producing dopamine, serotonin and anandamide.

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Re: Is Parkinson's an anandamide deficiency?

Post by dick » Sat Aug 17, 2024 8:03 am

I finished reading the supplement section in John Coleman’s book and I noticed one thing. He had nothing to offer us using the Pauling Protocol! What we are doing is his protocol. After reading this, I had an aha moment. I began researching this and came upon this article written by: Kaitlyn Berkheiser — Updated on March 15, 2023 titled “12 Dopamine Supplements to Boost Your Mood”
In it she lists the nutrients needed to boost dopamine levels in your body. Now, everything she listed were on the “Pauling Protocol” except five; the main two probiotics and mucuna pruriens.
Researching mucuna pruriens, I found that mucuna pruriens have the greatest effect on raising dopamine levels in our bodies. I also found that it may cause blood pressure levels to go down! This is perfect for me as I have high blood pressure. It also says that four grams a day is the dose. This is a win-win for me! I ordered it on Amazon and will tell you how it works in a later article.

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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Tue Aug 20, 2024 12:16 pm

Dick,

I credit you for bringing coconut oil (thru Fife's book) to my attention. I think it is important knowledge.

I have been using Dr. Fife's dietary plan for about a year now. I also have read all his books on coconut oil. I apply the Coconut Ketogenic Diet by Dr, Fife. My numbers have been slightly high overall cholesterol numbers (200). I use carbs at 50g - 80g. I try for a fats of 40% - 50%.
My concern or question is whether the high fat diet is really good for Alzheimer's/memory, since I am quite convinced that Ketones cannot be used for energy, and are in fact waste, a by-product of fat metabolism. When you burn fat without sufficient vitamin B5 you go into ketosis. I've gone through Fife's references looking for the answer, but so far to no avail.

No doubt there is magic in coconut oil.

My wife has halved her dose of levadopa, and we substituted the "natural" Dopa in mucuna puriens instead. Let me know how the high dose (4 grams) works out for you!

If you find anything that raises anandamide levels, I am all ears.
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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Tue Aug 27, 2024 1:53 pm

To the question of whether a high fat diet is helpful or harmful for Alzheimer's patients.

The Medical Medium states that the most probably cause of Alzheimer's, Parkinson's and Dementia are deposits of heavy metal toxins in the brain (e.g. mercury, aluminum, lead, copper, etc.)

As a thought experiment. If you are an Alaskan Eskimo without these heavy metals in the brain, then according the Medical Medium information you can eat all the fat you can tolerate without causing Alzheimer's or making dementia worse. This was apparently true prior to 1970.

The problem is that most westerners have metals in their brains. Fats, at least certain fats, "oxidize" when the fat in the blood gets close to these metal deposits. This flash oxidation in the brain causes a runoff of the metals, killing multitudes of neurons causing brain damage we call Alzheimer's, Parkinson's, ALS, and general dementia.

So the basic Medical Medium protocol is to both reduce fat and use a recommended "heavy metal detox smoothie" protocol to reduce metals in the brain.

Thus, if the fully saturated fat in coconut oil's doesn't spark or oxidize, that could help explain it's usefulness and function. I would bet oils that go rancid, react with oxygen, e.g. polyunsaturated fats, can oxidize. We should research saturated fats in this regard.

I believe it is dangerous and will make neurological conditions worse to take in a high fat diet.

Also, if Alaskan Eskimos suffer Alzheimer's, that would do much to counter the Medical Medium information regarding metals causing the neurological issues. I went looking, and while I didn't find much (if anything) on Alzheimer's, I did find a useful overview article that debunks many rumors about these Eskimo peoples being disease free.


https://www.mcdougallfoundation.org/new ... f-eskimos/

There Is No Eskimo Paradox

The human being is designed to thrive on a diet of starches, vegetables and fruits. The Eskimo experience serves as a testament to the miraculous strengths and adaptability of our bodies. We can survive on raw and cooked meat, but we thrive on starches, vegetables and fruits. These hardy people survived living at the edge of the nutritional envelope, but were not in good health. Here are some of the health costs they paid:

Eskimos Suffer from Atherosclerosis

Eskimos Suffer from Severe Bone Loss

Eskimos Are Infected with Parasites

Meat-derived Chemical Pollution

Since the 1970s the diet of the Eskimo has contained high levels of toxic, organic pollutants and heavy metals. These lipophilic chemicals are attracted to and concentrated in the fatty tissues of land and sea animals. As a direct result of the traditional Eskimo diet (now contaminated by industry wastes), the bodies of these Arctic people contain the highest human concentrations of environmental chemicals found anywhere on Earth: “levels so extreme that the breast milk and tissues of some Greenlanders could be classified as hazardous waste.” Eskimo women have been found to have levels of PCBs in their breast milk five to ten times higher than women in southern Canada. These chemicals cause and promote many forms of cancer and cause brain diseases, including Parkinson’s disease.
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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Wed Aug 28, 2024 11:14 am

It turns out that saturated fats are far less prone to oxidation than other forms of fat.
Because saturated fats are not susceptible to lipid peroxidation, they have not been found to be involved in these mechanisms.
Which fats are most likely to oxidize?

Unsaturated fats are more prone to rancidity compared to saturated fats due to their chemical structure and susceptibility to oxidation.

Double bonds: Unsaturated fats contain one or more double bonds in their fatty acid chains.

Saturated lipids are much more stable to oxidation than unsaturated lipids, which makes them desirable in foods very susceptible to oxidation such as frying oils (2, 8, 36). Double bonds increase the susceptibility of FAs to oxidation, with an increasing number of double bonds increasing oxidative susceptibility.May 7, 2015
There is a conundrum however, lauric acid is supposedly highly "combustible" in that it oxidizes quickly and coconut oil is the primary source?!?!
Coconut oil is made up of about 90% saturated fats and 9% unsaturated fats. However, the saturated fats in it differ from saturated fats in animal fats. Over 50% of the fats in coconut oil are medium chain fatty acids, such as lauric acid (12:0). Coconut oil is the highest natural source of lauric acid.


Conclusions: In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.

Something seems wrong in this "science." Coconut oil is 90% saturated fat (good), and saturated fat is immune to lipid peroxidation (good), yet lauric acid in experiments is the fat most prone to oxidation? And coconut oil is the main source ?!? Does not compute.
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Re: Is Parkinson's an anandamide deficiency?

Post by pamojja » Wed Aug 28, 2024 4:17 pm

Conclusions: In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.
What is he source of this statement?

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Re: Is Parkinson's an anandamide deficiency?

Post by dick » Thu Aug 29, 2024 9:48 am

The brain uses fat as a fuel source. As per Dr, Fife if the brain were to run out of fat, it would die. The only problem is I overlooked the one thing that is important is timing. The use of coconut oil is a timing event. You should use the coconut oil throughout the day. Coconut oil is good for about three- or four-hours' worth of energy.

This is probably where I went wrong! I had a stroke last month (July) and I was put on blood thinners. My blood pressure mysteriously went from 124/90 to 187/101. But I can only think it's because of the many pills that I take! If you take coconut oil your cholesterol settles in around 200. Which by the way, doctors want you on a statin (which I refuse). It is said that people with a cholesterol reading of 200 live the longest.

I am taking three grams of Mucuna Pruniens. It has settled my shakes quite a bit, but I can't say any further if it's because I'm not working out. I take too many pills and sometimes think it's maddening! When I workout (aerobically), it causes my heart rate to increase and my shakes to increase.

I don't know where you got your Lauric Acid info but I think it's worth looking into. Lauric Acid is the whole thing that oil pulling is all about! The lauric Acid is what is killing the bacteria in your mouth! The Lauric Acid in coconut oil is about 53%'

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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Thu Aug 29, 2024 1:39 pm

Conclusions: In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.
What is he source of this statement?

Google AI leading to these papers:


Differential oxidation of individual dietary fatty acids in humans
https://www.sciencedirect.com/science/a ... 6523067990


Conclusions:

In summary, lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized. Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.

Coconut oil and palm oil's role in nutrition, health and national development: A review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044790/
Herein lies the uniqueness of coconut oil. Coconut oil is made up of about 90% saturated fats and 9% unsaturated fats. However, the saturated fats in it differ from saturated fats in animal fats. Over 50% of the fats in coconut oil are medium chain fatty acids, such as lauric acid (12:0). Coconut oil is the highest natural source of lauric acid. Lauric acid and its derivative monolaurin constitute around 50% of coconut fat-derived lipid.

Also see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166560/
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Re: Is Parkinson's an anandamide deficiency?

Post by ofonorow » Thu Aug 29, 2024 2:23 pm

The brain uses fat as a fuel source. As per Dr, Fife if the brain were to run out of fat, it would die. The only problem is I overlooked the one thing that is important is timing. The use of coconut oil is a timing event. You should use the coconut oil throughout the day. Coconut oil is good for about three- or four-hours' worth of energy.
I could be wrong, but if you reread Fife, in his opinion, this is because of ketosis. His idea is to keep ketosis going 24/7. Coconut oil does promote ketosis. He believes that ketones (lipid metabolisim "waste" products) provide energy for the brain.

Admittedly, the highly controversial perspective of the Medical Medium's source is A) the brain is mostly carbohydrate, and B) the brain only uses glucose for energy (and cooling). The exception is that the brain can run for a short time on adrenaline.

So either the Medical Medium is wrong (Note: MM never mentions ketones or ketosis even once in all eight books. Note the last two books are devoted to saving the brain) or Fife is wrong if he really said, "The brain uses fat as a fuel source." The idea that if the brain were to run out of fat, it/we would die is demonstrably false.

My reading of Fife from STOP ALZHEIMER'S NOW is that he understood that he brain cannot use fat as a fuel source, but does accept the dogma that "ketones" can power brain function and save brain cells.

I will use Kindle and find Fife's statements in this regard to clarify this issue.

Normally the brain uses glucose to satisfy its energy needs. If glucose is not available, one of the only other sources of fuel it can use is ketone bodies or ketones. Other organs and tissues in the body can utilize fat for energy, but not the brain—it must have either glucose or ketones

Fife, Bruce. Stop Alzheimer's Now! (pp. 161-162). Piccadilly Books, Ltd. Kindle Edition.
What I think I know is that the brain uses glucose as its only fuel source and if the brain were to run out of glucose, we'd die. Fife agrees, but has bought into the idea that ketones can also power the brain.

I looked into where this idea came from, and it was a person with zero blood sugar whose brain was working.

The Medical Medium explains that the brain stores a form of glucose, like glycogen in the liver. Our brains use this glucose storage when supplies of glucose in the diet are scarce. This is still unknown to our science.

This is probably where I went wrong! I had a stroke last month (July) and I was put on blood thinners. My blood pressure mysteriously went from 124/90 to 187/101. But I can only think it's because of the many pills that I take! If you take coconut oil your cholesterol settles in around 200. Which by the way, doctors want you on a statin (which I refuse). It is said that people with a cholesterol reading of 200 live the longest.
With Pauling and the medical medium in mind, you went wrong by not taking optimal vitamin C (which is at least 40 mg/kg daily) and eating a high fat diet.

I am taking three grams of Mucuna Pruniens. It has settled my shakes quite a bit, but I can't say any further if it's because I'm not working out. I take too many pills and sometimes think it's maddening! When I workout (aerobically), it causes my heart rate to increase and my shakes to increase.
Mucuna Pruniens is a "natural" form of L-Dopa, but Big Pharma says it doesn't reach the brain as well as the levedopa/carbidopa drug. In any case, you risk keeping your own production of dopamine diminished by taking either. The information in this regard from Coleman seems pertinent. If I can get my wife off external forms of L-Dopa, I'd be happy.
I don't know where you got your Lauric Acid info but I think it's worth looking into. Lauric Acid is the whole thing that oil pulling is all about! The lauric Acid is what is killing the bacteria in your mouth! The Lauric Acid in coconut oil is about 53%'

Yes, and even the Medical Medium recommends Lauric Acid as reported earlier in this thread or in the Parkinson's thread.
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Re: Is Parkinson's an anandamide deficiency?

Post by dick » Sat Aug 31, 2024 12:49 pm

I weigh 190 lbs. I take 5 grams of vitamin C daily.

Where John Colman talks about detox he states that heat is good for detoxing. This is where I went wrong. I live in Florida and used a hot tub to warm up my fascia. He says that to not use it for more than fifteen minutes. I used it for two fifteen minute intervals! Of course "whose timing it."

I also started celebrating my "victories" with some ice cream! This added to my high fat diet! Plus it added to my carbs and took me out of ketosis.

John Coleman says in his book too take 5-htp, which helps with absorption. I ordered it and will take it and see what it does for me!

In His book, he also talks about aerobic exercise. He says that aerobic exercise at 76% of max heart rate also builds up anandamide. I was getting my aerobic exercise fill by riding a three wheeled bike nine miles a day and adding three times a week water aerobics for forty minutes. The only thing was i hit the tub before and after working out!


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