Vitamin-B6, Is it vital to CVD recovery?

[skwoodwiva]

I stumbled on this today. Startled I am.
https://www.google.com/url?sa=t&rct=j&q ... cOcq2sJUG9

Acquired Atherosclerosis: Theories of
Causation, Novel Therapies
Joseph G. Hattersley, M.A.
It says B6 deficiency plays a fundamental role in acquired atherosclerosis. Yet does support PT also. From early 90s it seems.

Hmm, I barely get 2 mg in my current B supplements. This says I need 50 minimum. But more like 100 or more!

Cardio-C appears to have none.
Heart Tech has 25 per 3 g AA.

Is P5P the best form?

[pamojja]

Is P5P the best form?

P-5-P, also known as pyridoxal and pyridoxamine are the more bioavailable forms. Not to confusie with pyridoxine, the usual lesser form.

[Frodo]

Vitamin B6 in combination with folic acid and vitamin B12 lowers homocysteine. Homocysteine is a decisive risk factor for heart disease. Best kept under 10 umol/l. Target: 5 umol/l.
That's why I take it.
Do you know your homocysteine value?

[skwoodwiva]

I am trying to economize on B6 supplementation. Is larger dosing on the cheap HCL form safe for older people? Say 100 to 200 mg a day?

[pamojja]

Say 100 to 200 mg a day?

Below 200 mg seems to be safe. See what LPI has to say.

Regarding Pyroluria I heard from Trudy Scott that in her experience 100 mg of pyridoxal is equally effective as 500 mg of pyridoxin. Also see this study: https://www.ncbi.nlm.nih.gov/m/pubmed/28716455/

[Frodo]

skwoodwiva
Have you measured your vitamin B6 level? My level was OK, at most too high. But my homocysteine level was 15,7. Much too high. Therefore I took infusions with vitamin B6, B9 and B12. What about your homocysteine level?

[skwoodwiva]

skwoodwiva
Have you measured your vitamin B6 level? My level was OK, at most too high. But my homocysteine level was 15,7. Much too high. Therefore I took infusions with vitamin B6, B9 and B12. What about your homocysteine level?

My provider thinks this stat cannot be in my normal medical record. But I think about 15 was what I was told about June.
How low are you now?

[skwoodwiva]

skwoodwiva
Have you measured your vitamin B6 level? My level was OK, at most too high. But my homocysteine level was 15,7. Much too high. Therefore I took infusions with vitamin B6, B9 and B12. What about your homocysteine level?

My provider thinks this stat cannot be in my normal medical record. But I think about 15 was what I was told about June.
How low are you now?

I order p5p (purebulk) & will do maybe 50 mg. Not sure where to start...
As well as 9 400mcg & 12 1000mcg (Jarrow, b6 is only 1.5 of p5p) again not sure...

BTW Cobrazol topical pain killer, I am trying out for my shoulder. The Depo Medrol injection 2 months ago is now letting maybe 20% of the pain come back.
I may cut this new stuff with some DMSO too.
Not sure I want another injection of the same DM.
Rant on.
More polysorbate-80 drama: the Kenalog, best longest lasting one, Kaiser Permanente does not have without this adulteration.
As well as every vaccine they offer me. End rant.

[Frodo]

My homocysteine level declined to 9,3. And I changed my folic acid. Now I take Optimized Folate (5 L-Methyfolate) from LE. Tomorrow I'll measure again.

[Frodo]

I have forgotten. 15,7 were measured in the serum. Therefore the result could be faulty. Better is to measure in the plasma and to use a special blood "container". 9,3 were measured in the plasma (after infusions).

[jimmylesante]

I dropped my Homocysteine from 14 down to 9 in two weeks by simply reducing my animal protein intake to minimal.
If i remember correctly excess homocysteine is a major risk factor as it oxidises cholesterol.

[ofonorow]

We learn from Roger J. Williams book NUTRITION AGAINST DISEASE from the 70s that Vitamin B6 is a necessary co-factor (so is copper, and vitamin C is the main cofactor) in the body's manufacture of collagen. Williams reported on experiments with primates where depriving them of B6 created atheroslcerosis. So yes, a B6 "deficiency" can lead to atherosclerosis, again supporting the Pauling/Rath Unified Theory that the bodies lack of collagen, e.g. chronic scurvy, is at the root of heart disease. Usually supplies of B6 (and copper) are adequate, and it is the vitamin C deficiency which is paramount.

In any event, following Pauling's recommendation for "one or two Super-B Complex daily" should cover the B6 issue.

[Blanko]

Is it normal to feel such a powerful effect from 50 mg of P5P? The first dose felt superb, but every dose since has felt too strong. This is a supplement where I notice strongly the effect. Any others care to share their thoughts? Could be the effect is especially strong for me since I've been taking substantial doses of benfotiamine for the past weeks? Also have been taking zinc, magnesium and VC.

Edit: appears some of the issue is because I added the B6 while significantly dropping the B1 dose. Adding back the B1 is helping calm the body and reduce the tension from the overly strong B6.

Edit 2: just noticed the supplement in question has more of pyridoxine hydrochloride than P5P. I never take pyridoxine hydrochloride except missed it in this instance. Maybe it feels stronger and that's why it's used.

It's interesting how benfotiamine calms down the tension and potency of the pyridoxine hydrochloride dosage. Magnesium didn't touch it.

[ofonorow]

Interesting. Thank you for this observation.

The book HIGH B1 THERAPY FOR PARKINSON'S reveals that the benfotiamine form of vitamin B1 does not pass the blood brain barrier, and is thus not recommended for treatment of Parkinson's.