A new study suggests that IV/C given at the same time patients are given this antibiotic helps prevent the Acute Kidney Injury (AKI) that it can cause.
In severely ill patients receiving colistin according to a PK/PD-driven dosing approach, baseline renal impairment and older age strongly predict AKI occurrence, but concomitant administration of ascorbic acid markedly reduces AKI risk, allowing safer use of colistin.
Colistin-associated Acute Kidney Injury in Severely Ill Patients: A Step Toward a Better Renal Care? A Prospective Cohort Study. Clin Infect Dis. (2015) doi: 10.1093/cid/civ717 First published online: September 9, 2015