Does L-Citrulline compete with L-Lysine

The discussion of the Linus Pauling vitamin C/lysine invention for chronic scurvy

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DiverDown2
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Does L-Citrulline compete with L-Lysine

Post by DiverDown2 » Tue Jul 05, 2022 6:27 am

Does L-Citrulline compete with L-Lysine like L-Arginine does, or is it a different pathway?

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Re: Does L-Citrulline compete with L-Lysine

Post by ofonorow » Tue Jul 05, 2022 10:37 am

My incomplete understanding is that the "competition" between lysine and arginine has to do with absorption in the GI tract. In other words, they share the same pathway through the intestinal wall.

I have no idea if all aminos share this pathway, but, if you separate large amounts of other aminos from L-Lysine by 4 hours (the time it takes to digest proteins) you shouldn't have to worry about this kind of competition.

It turns out that arginine and lysine are probably "antagonistic" in another way. Human knowledge (therefore fallible) is that while lysine is "anti-viral," and actually twists viral DNA in one direction, Arginine promotes viruses, by twisting their DNA in another direction.

No idea whether citrulline plays in this game.
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Re: Does L-Citrulline compete with L-Lysine

Post by eDOC » Tue Jul 05, 2022 9:05 pm

DiverDown2 wrote:Does L-Citrulline compete with L-Lysine like L-Arginine does, or is it a different pathway?


@DiverDown2, Citrulline does not compete with Lysine. I don't know of your requirements, intentions of taking it. I would recommend giving Lysine a 1 week off, rest period if you have been taking it for more than 3/6 months.

eDOC!!


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Re: Does L-Citrulline compete with L-Lysine

Post by DiverDown2 » Thu Jul 07, 2022 5:45 am

Thanks for the reply, Taking Lysine as part of Pauling's Protocol.

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Re: Does L-Citrulline compete with L-Lysine

Post by ofonorow » Thu Jul 07, 2022 9:02 am

It is worth remembering (Thank you Linus!) that lysine is essential and we need at least 1 gram per day for life (to stay in nitrogen balance.) I'm not sure why eDOC recommends taking some time off high dose lysine, but the reason I wrote my book is because of all the people who felt cured, stopped the Pauling therapy, and suffered heart attacks roughly six months after stopping.

Stopping for short periods is probably okay, but if you are prone to chronic scurvy (aka heart disease) I wouldn't stop for months.
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Re: Does L-Citrulline compete with L-Lysine

Post by DiverDown2 » Fri Jul 08, 2022 6:14 am

That puzzled me also, since Lysine is a Major part of Linus Protocol to keep LP-a from sticking, and I have High LP-a.


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