Statins and CoQ10 depletion
Dr. Langsjoen says that "All statin drugs (HMG-CoA reductase inhibitors) block the biosynthesis of both cholesterol and CoQ10, which explains their common side effects of fatigue, muscle pain, and a worsening of heart failure" and adds that "the current epidemic of congestive heart failure in the US can be termed statin cardiomyopathy".
The Life Extension Foundation estimates that about 5 million have CHF, about 1 million are hospitalized with CHF annually and that "nearly 53,000 die directly from CHF each year".
Should you supplement with CoQ10?
After 24 years of treating patients with CHF, Dr. Langsjoen thinks that it makes sense for middle aged people to supplement CoQ10 as a preventative measure.
What form and what dose you consider depends on your individual therapeutic requirements. The most common form of supplemental CoQ10 is available in the form called ubiquinone.
Newer formulas use a form of CoQ10 called ubiquinol, a reduced form that may be more easily absorbed in the bloodstream. Lower preventative and therapeutic doses may be required due to increased absorption.
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