Effect of ascorbic acid on bone marrow-derived mesenchymal stem cell proliferation and differentiation

[ofonorow]

https://www.sciencedirect.com/science/a ... 2308701154

Mesenchymal stem cells (MSCs) derived from bone marrow are an important tool in tissue engineering and cell-based therapies because of their multipotent capacity. Majority of studies on MSCs have investigated the roles of growth factors, cytokines, and hormones. Antioxidants such as ascorbic acid can be used to expand MSCs while preserving their differentiation ability. Moreover, ascorbic acid can also stimulate MSC proliferation without reciprocal loss of phenotype and differentiation potency.


The results demonstrate that MSC proliferation or differentiation depends on ascorbic acid concentration.