Emek wrote:This is where he is going wrong with his math. It's surface area of the sphere with density of lipid packing approximates the amount of liposomal membrane needed (you could also do sphere in a sphere too with delta of the radii being the membrane thickness and use density of the lipid packing).
The math I sent you before is simplified and assumes that vitamin c packs at the same density the lipids do (vitamin c is more compact than the lipids and ionic and packs much more densely).
This individual is missing a variety of points: 1. His math does not represent the system, 2. Loading rate is specific to liposome diameter and lipid material, there is no general rule for this, 3. My 1 kg water bottles does not have 4 kg of plastic to hold it, 4. This conversation is somewhat irrelevant as the liposomes work (we are interested in the outcome).
I think it's ironic that he states that the math is lengthy (this is true) but uses a single equation with one variable for his entire argument. The variables are packing density of lipid and vitamin c, liposome radius, pH, temperature, ionic strength of solution, and more. For instance, we us the same amount of lipid for half as much glutathione.
Another point of irony. If you plug in the numbers correctly to the website he provided,
http://www.liposomemodel.com, it supports our lipid / vitamin c ratio (I think he did not calculate molarity correctly and underestimated it).
The website also uses a different math model than his sphere in a sphere model.
Once again though, the liposomal c works and is proven clinically in university studies.
http://cctsi.ucdenver.edu/Public%20Documents/newsletters/CCTSI-Connections-FallWinter2013.pdf. This will be published soon.
I don't know how my car works in detail but it gets me to my destination.